Cinnarizine

Cinnarizine is antihistaminic agent. Cinnarizine is mainly used for treatment of vomiting and vertigo.


Adult Dose
Dose: 25 to 75 mg
Single Dose: 50 (50)
Frequency: 8 hourly
Route: PO
Instructions: In Motion sickness half an hour before travelling.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Synthetic origin and belongs to Phenyl piperazine. It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Cinnarizine is 368.50.
Contraindications
'Cinnarizine is contraindicated in conditions like Hypotension,Parkinson''s disease.'
Effects
The severe or irreversible adverse effects of Cinnarizine, which give rise to further complications include Tardive dyskinesia, Parkinsonism, Extrapyramidal symptoms.Cinnarizine produces potentially life-threatening effects which include Respiratory depression, Convulsions, In wordination, Drowsiness. which are responsible for the discontinuation of Cinnarizine therapy.The signs and symptoms that are produced after the acute overdosage of Cinnarizine include Convulsions, Drowsiness, Respiratory depression, Dizziness, Hypopyrexia, Incoordination.The symptomatic adverse reactions produced by Cinnarizine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, GI upset, Hypotension, Depression, Unsteadiness.
Indications
'Cinnarizine is primarily indicated in conditions like Motion sickness, Peripheral arterial disease, Peripheral vascular disease, Raynaud`s syndrome, Vestibular disorders, Vestibular symptoms of central and peripheral origin, and can also be given in adjunctive therapy as an alternative drug of choice in Nausea and vomiting, Raynaud''s disease, Vertigo.'
Interactions
No data regarding the interactions of Cinnarizine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Caps Store at room temperature.
Warnings
Patients should observe caution while driving or performing other tasks requiring alertness, because may cause drowsiness. Cinnarizine should be used with caution in patients with liver impairment, dose should be reduced in patients with renal impairment. Avoid use in young children and use with caution in elderly patients.
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