Capreomycin

Capreomycin is an antimycobacterial cyclic peptide elaborated by Streptococcus capreolus. It consists of four active components its IA, IB, IIA, and IIB. The agent used clinically contains primarily I A and I B. itCapreomycin is given through deep IM (intramuscular) route in the treatment of tuberculosis as part of multidrug regimen, when resistance to or toxicity from primary drugs has developed. Capreomycin is given through deep IM (intramuscular) route. Bacterial resistance to it develops when Capreomycin is given alone.

Brands
Adult Dose
Dose: 1 gm
Single Dose: 1 (1)
Frequency: 24 hourly
Route: IM
Instructions: For treatment of tuberculosis (TB):This dose is given for 60 to 120 days. After this time, 1 gram of capreomycin is injected into the muscle 2 or 3 times a week. This medicine must be given with other medicines to treat tuberculosis (TB).
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin. . The Molecular Weight of Capreomycin is 1324.41.
Contraindications
Capreomycin is contraindicated in conditions like Allergy,Hypersensitivity to the drug.
Effects
The symptomatic adverse reactions produced by Capreomycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Urticaria, Hypersensitivity reactions.
Indications
Capreomycin is primarily indicated in conditions like Severe or recurrent duodenal and gastric ulcertion.
Interactions
Capreomycin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCisplatinIncreased risk of nephrotoxicity and ototoxicity when capreomycin given with platinum compounds (e.g Cisplatin).Colistin (Sulphate & Sulphomethate Na)Increased risk of nephrotoxicity when capreomycin given with colistin.Estrogens ConjugatedCapreoycin possibly reduce contraceptive effect of estrogen (risk possibly small).GentamicinRespiratory paralysis and renal dysfunction risk is increased if this combination is used.MajorThis combination should be avoided.Polymyxin B (Sulphate)Increased risk of nephrotoxicity when capreomycin given with Polymyxin B (Sulphate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in a well closed container, . Protect from Sunlight, Moisture and Heat.
Warnings
Capreomycin should be used with caution in patients with renal impairment; hepatic impairment; auditory impairment; monitor renal, hepatic, auditory and vestibular function and electrolytes; pregnancy (teratogenic in animals, use only if potential benefit outweighs risk) and breast-feeding.
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