Co-Fluampicil

Co-Fluampicil is a mixture of equal parts by mass of flucloxacillin and ampicillin, used to produce a wider spectrum of activity. Ampicillin is a beta-lactam antibiotic active against certain gram +ve and gram -ve organisms, but is inactivated by penicillinases. Flucloxacillin, however, is a penicillinase-resistant antibiotic and thus effective in infections caused by penicillin-resistant staphylococci.

Brands
Adult Dose
Dose: 250 mg/day
Single Dose: 250 (250)
Frequency: 6 hourly
Route: PO
Instructions: Should be taken 1 hour before meal.
Neonatal
Paedriatic
Characteristics
.
Contraindications
Co-Fluampicil is contraindicated in conditions like Penicillin hypersensitivity.
Effects
The symptomatic adverse reactions produced by Co-Fluampicil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Fever, Rashes, Urticaria, Hemolytic anemia, Thrombocytopenia, Neutropenia, Hypersensitivity reactions, Cholestatic Jaundice, Angioedema, Joint pain, Hepatitis, Anaphylaxis, Interstitial nephritis, Convulsions (especially with high doses or in severe renal impairment), Antibiotic-associated colitis.
Indications
Co-Fluampicil is primarily indicated in conditions like Schizophrenia and other psychoses.
Interactions
No data regarding the interactions of Co-Fluampicil was found.
Interfrence
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Co-Fluampicil should be used with caution in patients with history of allergy; erythematous rash common in grandular fever; cytomegalovirus infections; acute or chronic lymphocytic leukaemia; renal impairment (reduce dose if severe); porphyria; cholestatic jaundice. CSM has advised that cholestatic jaundice may occur up to several weeks after treatment with Co-Fluampicil has been stopped.Administration for more than 2 weeks and increasing age are risk factors.
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