Memantine

Memantine (HCl) is a derivative of amantadine. Similar to amantadine, it inhibits enzyme N-methyl-D-aspartate receptors, that affects glutamate transmission. Memantine (HCl) is used in the treatment of mild to moderate dementia in Alzheimer`s disease. Memantine (HCl) is also used in the management of Parkinsonism and cerebral spasticity.


Adult Dose
Dose: 5 mg
Single Dose: 5 (5)
Frequency: 24 hourly
Route: PO
Instructions: Initially for 1 week.
Neonatal
Paedriatic
Characteristics
Memantine also known as Amantadine. Memantine (HCl) is the derivative of Memantine. It is of Synthetic origin. . The Molecular Weight of Memantine is 215.80.
Contraindications
Memantine is contraindicated in conditions like Breast feeding.
Effects
The symptomatic adverse reactions produced by Memantine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tiredness, Headache, Vomiting, Anxiety, Confusion, Hallucination, Cystitis, Hypertonia.
Indications
'Memantine is primarily indicated in conditions like Alzheimer''s disease, Induction and maintenance of anaesthesia, Parkinsonism.'
Interactions
Memantine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmantadine (HCl)ApomorphineEffects of Apomorphine possibly enhanced by Memantine (HCl).Ketamine (HCl)PergolideLikely interaction of MEMANTINE increasing the DOPAMINERGIC effect of PERGOLIDE MESILATE. May need to avoid combinationMajor These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Urinanalysis
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Memantine (HCl) should be used with caution in patients with renal impairment (avoid if severe); pregnancy; epilepsy.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.