Galantamine

Galantamine is a reversible inhibitor of cholinestrase activity and it also has nicotinic receptor agonist properties. The actions and general properties similar to neostigmine. Galantamine is used in the treatment of mild to moderate dementia in Alzheimer`s disease and in various neuromuscular disorders.


Adult Dose
Dose: 4 mg
Single Dose: 4 (4)
Frequency: 12 hourly
Route: PO
Instructions: Four weeks later, the dose should be increased to 8 milligrams twice a day. After waiting an additional four weeks, the doctor may increase the dose to 12 milligrams twice a day if necessary.
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin. . The Molecular Weight of Galantamine is 368.30.
Contraindications
Galantamine is contraindicated in conditions like Breast feeding,Adjunct in treatment of opioid dependance.
Effects
The symptomatic adverse reactions produced by Galantamine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Fatigue, Anorexia, Diarrhea, Tremors, Abdominal pain, Bradycardia, Weight LossX, Dyspepsia, Nausea and vomiting, Muscle cramps, UTI, Hypertension, dyspepsia.
Indications
'Galantamine is primarily indicated in conditions like Mild to moderate dementia in alzheimer''s disease, and can also be given in adjunctive therapy as an alternative drug of choice in Muscle relaxation.'
Interactions
Galantamine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcepromazine (Maleate)ChlorprothixeneChlortetracycline (HCl)Glycopyrrolate These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Galantamine should be used with caution in patients with hepatic impairment (avoid if severe); sick sinus syndrome or other supraventricular conduction abnormalities; susceptibility to peptic ulcer; asthma, chronic obstructive pulmonary disease; may exacerbate extrapyramidal symptoms; hepatic impairment.
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