Lofexidine

Lofexidine (HCl) is an alpha-2 receptor agonist similar to clonidine. It appears to act centrally to produce reduction in sympathetic tone, but reduction in blood pressure is less marked. Lofexidine (HCl) is used for the symptomatic management of opiod withdrawal.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
Lofexidine (HCl) is the derivative of Lofexidine. It is of Synthetic origin. . The Molecular Weight of Lofexidine is 259.13.
Contraindications
Lofexidine is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Lofexidine, which give rise to further complications include Bradycardia, Prolongation of QI interval.The symptomatic adverse reactions produced by Lofexidine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Dry mouth, Bradycardia, Hypotension, Rebound hypertension on withdrawl, Dry mucous membrane (perticularly dry mouth, throat, and nose), Dry mouth.
Indications
Lofexidine is primarily indicated in conditions like Hypertension, Opiate withdrawal syndrome.
Interactions
No data regarding the interactions of Lofexidine was found.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Lofexidine should be used with caution in patients with severe coronary insufficiency, recent myocardial infarction, cerebrovascular disese, marked bradycardia (monitor pulse rate frequently); renal impairment; history of depression (on longer tretment); pregnancy and breast feeding; withdraw gradually over 2-4 days (or longer) to minimize risk of rebound hypertension and associated symptoms. Donot drive because Lofexidine may cause drowsiness. Withdrawl of lofexidine therapy should be gradual.
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