Botulinum B Toxin

Botulinum B Toxin is an exotoxin produced by germinating spores and growing cells of Clostridium botulinum. It binds to presynaptic terminals of the central nervous system and inhibits the calcium-ion mediated release of acetylcholine at the motor nerve terminals, leading to flaccid paralysis of the affected muscles. Paralysis persists for about 2-3 months (until new nerve terminals form). The actions and uses are similar to those of Botulinum type A toxin, but due to antigenically distinct they have the potential for use in patients who develop resistance to botulinum toxin treatment due to the development of antibodies of type A toxin.

Brands
Adult Dose
Dose: 2500 to 5000 units
Single Dose: 3800 (3750)
Frequency: As recommended.
Route: IM
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Natural origin and belongs to Purified neurotoxin complex. . The Molecular Weight of Botulinum B Toxin is 150804.00. It is weakly acidic drug.
Contraindications
Botulinum B Toxin is contraindicated in conditions like Pregnancy,Breast feeding,Prophylaxis of angina; adjunct in CHF.
Effects
Botulinum B Toxin produces potentially life-threatening effects which include Muscle weakness. which are responsible for the discontinuation of Botulinum B Toxin therapy.The symptomatic adverse reactions produced by Botulinum B Toxin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Dyspepsia, Dysphagia, Taste disturbances, Neck pain, Voice changes, Worsening torticollis, Myasthenia, Dry mouth, dyspepsia.
Indications
Interactions
No data regarding the interactions of Botulinum B Toxin was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 15°C. Do not Freeze.
Warnings
Inadvertant injection into a blood vessel; tolerance may occur. It should be given with extreme caution to pateints with neurological disorders
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