Entacapone

Entacapone is a peripheral inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of dopamine and levodopa. It prevents the peripheral breakdown of levodopa, allowing more levodopa to reach the brain. Entacapone is used as an adjunct in combination preparation of levodopa and dopa decarboxylase inhibitors, in patients with Parkinson`s disease who experience end-of-dose deterioration and cannot be stabilised on these combinations.

Brands
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Adult Dose
Dose: 200 mg
Single Dose: 200 (200)
Frequency: As recommended.
Route: PO
Instructions: 200 mg tablet of entacapone should be administered concomitantly with each levodopa/carbidopa dose to a maximum of 8 times daily (200 mg x 8 = 1600 mg per day).
Neonatal
Paedriatic
Characteristics
Entacapone also known as Entacapona, Entacapona, Entacapona. . It is of Synthetic origin and belongs to COMT Inhibitor. . The Molecular Weight of Entacapone is 305.29. Its pKa is 4.5.
Contraindications
Entacapone is contraindicated in conditions like Phaeochromocytoma,Neuroleptic malignant syndrome,Pregnancy,Hepatic impairment,Breast feeding.
Effects
The severe or irreversible adverse effects of Entacapone, which give rise to further complications include Hallucinations, Hallucinations, Severe illergic reactions, Difficulty in breathing, Tightness in the chest, Severe Pecsistant a watery diarrhoea, Change in the appearance of the mole.The symptomatic adverse reactions produced by Entacapone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Nausea, Vomiting, Diarrhea, Constipation, Abdominal pain, Dry mouth, Nausea and vomiting, Dyskinesia, Rarely hepatitis, Colored (reddish-brown) urine, Dry mouth, dizziness.
Indications
'Entacapone is primarily indicated in conditions like Parkinson''s disease.'
Interactions
Entacapone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementApomorphineEffects of Apomorphine possibly enhanced by Entacapone. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Decreased serum iron concentrations
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store at room temperature, . Protect from Sunlight, Moisture and Heat.
Warnings
Concurrent levodopa dose may need to be reduced by 10-30%. DRIVING: Drowsiness (include sudden onset of sleep) may affect performance of skilled task; patients who are affected should not drive or undertake potentially dangerous activities.
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