Choline Magnesium Trisalicylate

Choline Magnesium Trisalicylate is a combination of choline salicylate and magnesium salicylate. It relieves mild to moderate pain, reduces fever and inflammation or swelling. Choline Magnesium Trisalicylate is effective in the treatment of gout, rheumatic fever, rheumatoid arthritis and muscle injuries.

Brands
LEDERPLEX DAVIPLEX WELMATON
Adult Dose
Dose: 1.5 mg
Single Dose: 1.5 (1.5)
Frequency: 12 hourly
Route: PO
Instructions:
Neonatal
Dose: Should be avoided
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Frequency:
Route:
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Paedriatic
Dose: Should be avoided
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Frequency:
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Characteristics
. It is of Synthetic origin and belongs to Mg HydroxyBenzoic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Choline Magnesium Trisalicylate is 539.80. Its pKa is 3.96.
Contraindications
Choline Magnesium Trisalicylate is contraindicated in conditions like Peptic ulcer,Renal failure,Congestive heart failure.
Effects
The severe or irreversible adverse effects of Choline Magnesium Trisalicylate, which give rise to further complications include Gastric hemorrhage, Peptic ulceration, Peptic perforation.Choline Magnesium Trisalicylate produces potentially life-threatening effects which include Anaphylactoid reactions, Allergic reactions, Bronchospasm. which are responsible for the discontinuation of Choline Magnesium Trisalicylate therapy.The signs and symptoms that are produced after the acute overdosage of Choline Magnesium Trisalicylate include Vomiting, Coma, Acute renal failure, Confusion, Epigastric pain, Hyperventilation, Irritability, Electrolyte disturbances, Hyper or hypoglycemia, Hyperpyrexia, Oliguria, Light headedness.The symptomatic adverse reactions produced by Choline Magnesium Trisalicylate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Tinnitus, Light headedness, Fluid retention.
Indications
Choline Magnesium Trisalicylate is primarily indicated in conditions like Osteoarthritis, Pain, Rheumatoid arthritis, Soft tissue rheumatism.
Interactions
No data regarding the interactions of Choline Magnesium Trisalicylate was found.
Interfrence
Reduction of the granulocyte count has been reported. Reversible elevation of hepatic transaminases, alkaline phosphatase. Urine testing for Bilirubin and Ketones and may produce a false positive test for sugar.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Syrups Store in a well closed container, at room temperature, . Protect from Sunlight, Moisture and Heat.
Warnings
Choline magnesium trisalicylate should be used with caution in patients with chronic renal insufficiency, gastric ulcer, severe anemia, patients intolerant to salicylate. Avoid aspirin compounds in patient with history of blood coagulation defects and if patients taking anticoagulants.
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