Oxcarbazepine

Oxcarbazepine is an antiepileptic that is used as an adjunctive treatment of partial seizures with or without secondary generalised tonic-clonic seizures.


Adult Dose
Dose: 1200 mg/day
Single Dose: 1200 (1200)
Frequency: As recommended.
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Oxcarbazepine is 252.27.
Contraindications
Oxcarbazepine is contraindicated in conditions like Hypersensitivity to any component of product.
Effects
The symptomatic adverse reactions produced by Oxcarbazepine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Drowsiness, Ataxia, Alopecia, Diarrhea, Constipation, Abdominal pain, Rashes, Confusion, Urticaria, Depression, Tremor, Diplopia, Asthenia, Nausea and vomiting, Acne, Agitation, Nystagmus, Amnesia, Vision disturbances, Hyponatremia.
Indications
Oxcarbazepine is primarily indicated in conditions like Epilepsy, Iron deficiency anaemia.
Interactions
Oxcarbazepine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDolutegravirdecrease Dolutegravir level coadministration should be avoidedFelodipineAfter repeated coadministration of Oxcarbazepine, the AUC of felodipine was lowered by 28%.Verapamil (HCl)Verapamil produced a decrease of 20% of the plasma levels of Oxcarbazepine. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased in Serum AminotransferaseElevated liver enzymes
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Oxcarbamazepine should be used with caution in hypersensitivity to carbamazepine; avoid abrupt withdrawl; hepatic impairment; renal impairment; pregnancy; breast-feeding; elderly; hyponatraemia (monitor plasma-sodium in patients at risk), heart failure (monitor body weight), cardiac conduction disorders. Blood, Hepatic and Skin disorders: Patients and their carers should be told how to recognise signs of blood hepatic and skin disorders, and advised to seek medical attention if symptoms such as lethargy, confusion, muscular twitching, fever, sore throat, rash, blistering, mouth ulcer and bruising or bleeding develop.
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