Eletriptan

Eletriptan is a selective serotonin (5HT-1) agonist. Eletriptan is given orally in the treatment of acute migraine attacks. It may be used during the established headache phase of an attack and is the preferred treatment in those who fail to respond to conventiaonal analgesics.


Brands
Adult Dose
Dose: 20 to 40 mg
Single Dose: 30 (30)
Frequency: 24 hourly
Route: PO
Instructions: For migrain: The maximum daily dose should not exceed 80 mg.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Triptamines and derivatives. . The Molecular Weight of Eletriptan is 382.52.
Contraindications
Eletriptan is contraindicated in conditions like Peripheral vascular disease,Uncontrolled hypertension,Severe hypertension associated with renal disease,Chronic intractable hypoglycaemia.
Effects
The symptomatic adverse reactions produced by Eletriptan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Ataxia, Nausea, Anorexia, Myalgia, Dyspnea, Restlessness, Insomnia, Tinnitus, Abdominal pain, Dry mouth, Confusion, Pruritus, Bradycardia, Pharyngitis, Hallucination, Dyspepsia, Hypotension, Transient increase in blood pressure, Depression, Tremor, Asthenia, Arthralgia, Glossitis, Edema, Rhinitis, Euphoria, Chest pain, Agitation, Wheezing, Muscle pain, Increased urinary frequency, Dry mouth, Confusion, dyspepsia, Ataxia.
Indications
Eletriptan is primarily indicated in conditions like Long-term treatment of reflux oesophagitis, Treatment of acute migraine attacks.
Interactions
Eletriptan is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementErythromycinKetoconazoleVORICONAZOLEVoriconazole may increase the serum concentration of eletriptan by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of eletriptan if voriconazole is initiated, discontinued or dose changed.Vortioxetineincreases the level of vortioxetinemonitor closely, use alternative These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
None well documented
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store at room temperature, Below 30°C. Protect from Sunlight and Moisture.
Warnings
5HT1 agonists (e.g Eletriptan) should be used with caution in conditions which predispose to coronary artery disease (pre-existing cardiac disease), pregnancy and breast-feeding. 5HT1 agonists are recommended as monotherapy and should not be taken concurrently with other acute migraine therapies. Little information is available on the use of these drugs in the elderly (over 65 year). Caution is also required in mild or moderate hepatic impairment and renal impairment; not to be taken until 24 hours after stopping ergotamine-type prepration (ergotamine-type prepration not to be taken until 6 hours after Eletriptan)
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