Desloratadine

Desloratadine is an active metabolite of loratadine, a non-sedating antihistamine. It causes less sedation and psychomotor impairment than the older antihistamines because it penetrates the blood brain barrier only to a slight extent. Desloratadine is used for the symptomatic relief of allergic conditions such as urticaria and hay fever.


Adult Dose
Dose: 5 mg
Single Dose: 5 (5)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose: 1.25 1
Single Dose: 1.2 (1.25)
Frequency: As recommended.
Route: for 12 months to 5 year.
Instructions:
Characteristics
It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.
Contraindications
Desloratadine is contraindicated in conditions like Pregnancy,Porphyria,Breast feeding.
Effects
Desloratadine produces potentially life-threatening effects which include Arrhythmias, Anaphylaxis, Angioedema, Extrapyrimidal symptoms. which are responsible for the discontinuation of Desloratadine therapy.The symptomatic adverse reactions produced by Desloratadine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Fatigue, Myalgia, Palpitation, Dry mouth, Blurred vision, Urinary retensionX, Pharyngitis, GI disturbance, Dry mouth.
Indications
Desloratadine is primarily indicated in conditions like Perennial rhinitis, Urticaria, and can also be given in adjunctive therapy as an alternative drug of choice in Seasonal allergic rhinitis.
Interactions
No data regarding the interactions of Desloratadine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Antihistamines (e.g Desloratadine) should be used with caution in prostatic hypertrophy, urinary retention, epilepsy, glaucoma, pyloroduodenal obstruction, hepatic disease, dose reduction may be necessary in renal impairment. Children and the elderly are more susceptible to side-effects.
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