Chlorthalidone

Chlorthalidone is an antihypertensive agent. Chlorthalidone is a sulfonamide derivative. It has different chemical structure from thiazide but the same pharmacological actions as that of thiazide diuretic. It increases the urination and reduces the amount of water and sodium retained by the body. Chlorthalidone is administered orally.

Brands
ATLIN PLUS BLOKIUM-DIU BLOKIUM-DIU TENORET-50 NORMITAB PLUS CO-PULSE CO-PULSE CARDIOLITE PLUS
Adult Dose
Dose: 0.35 to 2.85 mg/kg
Single Dose: 1.6 (1.6)
Frequency: 24 hourly
Route: PO
Instructions: -
Neonatal
Dose: 2.5 mg/kg
Single Dose: 2.5 (2.5)
Frequency: 24 hourly
Route: oral
Instructions:
Paedriatic
Dose: 2.5 mg/kg
Single Dose: 2.5 (2.5)
Frequency: 24 hourly
Route: Oral
Instructions: -
Characteristics
Chlorthalidone also known as Chlortalidone. . It is of Synthetic origin and belongs to Sulphonamide. It belongs to NaCl cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Thiazide pharmacological group.The Molecular Weight of Chlorthalidone is 338.80. Its pKa is 9.4.
Contraindications
Chlorthalidone is contraindicated in conditions like Allergy,Diabetes mellitus,Anuria.
Effects
The severe or irreversible adverse effects of Chlorthalidone, which give rise to further complications include Hypersensitivity reactions.Chlorthalidone produces potentially life-threatening effects which include Hypokalemia, Idiosyncratic hypersensitivity, Hyperosmolar non-ketotic diabetic coma, Hypokalemia. which are responsible for the discontinuation of Chlorthalidone therapy.The signs and symptoms that are produced after the acute overdosage of Chlorthalidone include Coma, Jaundice, Hypokalemia, Hypochloremic alkalosis, Hypersensitivity reactions, Lethargy.The symptomatic adverse reactions produced by Chlorthalidone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Vertigo, Headache, Fatigue, Nausea, Diarrhea, Constipation, Dry mouth, Impotence, Muscle cramps, Myopathy, Rhabdomyolysis, Hypokalemia, Azotemia, Dry mouth, dizziness.
Indications
Chlorthalidone is primarily indicated in conditions like Edema, Essential hypertension, Heart failure, Hypertension, Idiopathic hypercalciuria, Menieres disease, Mild to moderate chronic heart failure, Nephrogenic and partial pituitary diabetes insipidus, Nephrolithiasis, Oedema.
Interactions
Chlorthalidone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAllopurinolAmphotericin BAstemizoleCarbenoxolone (Na)Celiprolol (HCl)DiazoxideFosinopril (Na)Halofantrine (HCl)IbuprofenIndacaterolconcomitant therapy may increase risk of hypokalemiamonitor closelyIndomethacinLithiumNebivolol (HCl)Concurrent use may decrease the extent of absorption of Nebivolol (HCl).Noradrenaline (Acid Tartrate)PimozideSotalol (HCl)TerfenadineTetracycline (HCl)Thiamine HCl (Vitamin B1)Chlorthalidone have been associated with decreased thiamin levels in the body by increasing urinary excretion and possibly by decreasing absorption and increasing metabolism.Tubocurarine (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Chlorthalidone should be used with caution in patients with gout, diabetes or any allergy especially to sulfa medicines. Thiazide diuretics increase sensitivity to sunlight, avoid prolonged sun exposure, use sunscreen and wear protective clothing. This medication should be used during pregnancy or lactation only if clearly needed. Avoid any drugs that increase heart rate or cause excitation like decongestants (found in cough and cold products) because it may counteract blood pressure medicine.
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