Chlortetracycline (HCl)

Chlortetracycline is a broad spectrum tetracycline antibiotic. Tetracyclines are derivative of polycyclic naphthacenecarboxamide. They are bacteriostatic and effective against many gram positive and gram negative bacteria. Chlortetracycline is isolated from Streptomyces aureofaciens. It was introduced in 1948 and was the first of the tetracycline group to be discovered. Chlortetracycline (HCl) is used as an antibacterial and antiprotozoal administered orally, by intravenous injection, or applied topically to the conjuctiva. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Chlortetracycline (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the drug, it may result in ineffective treatment.

Brands
Adult Dose
Dose: 3.57 mg/kg
Single Dose: 3.6 (3.57)
Frequency: 6 hourly
Route: PO
Instructions: -
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Characteristics
. It is of Semi Synthetic origin and belongs to Tetracycline. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Opthalmic Products and Antibiotic, Tetracycline Derivative pharmacological group.The Molecular Weight of Chlortetracycline (HCl) is 515.30. Its pKa is 7.4.
Contraindications
Chlortetracycline (HCl) is contraindicated in conditions like Systemic lupus erythematosus,Hypersensitivity,Renal impairment,Hepatic impairment.
Effects
The severe or irreversible adverse effects of Chlortetracycline (HCl), which give rise to further complications include Staining of developing teeth, Hypoplasia of enamel, Superinfection, Sever sun burn, Gastric discomfort.Chlortetracycline (HCl) produces potentially life-threatening effects which include Phototoxicity, Fatal liver damage, Anaphylaxis, effects on classified tissues, Hepatic necrosis, fatal neciosis, Fatal liver damage. which are responsible for the discontinuation of Chlortetracycline (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Chlortetracycline (HCl) include Hypotension, Nausea, Vomiting, Coma, Jaundice, Raised hepatic enzymes, Abdominal pain, Intestinal hemorrhage, Lethargy.The symptomatic adverse reactions produced by Chlortetracycline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Anorexia, Diarrhea, Skin rashes, Stomatitis, Vaginitis, Glossitis, Hemolytic anemia, Thrombocytopenia, Intracranial hypertension, Enterocolitis, Bulging fontanelle in Infants, Anogenital inflammatory lesions, Skin rashes, Vestibular problems.
Indications
Chlortetracycline (HCl) is primarily indicated in conditions like Acne, Bacterial infections, Genitourinary tract infections, GI infections, Opthalmic infections, Pneumonia, Pyogenic infections, Respiratory tract infections, Soft tissue infections.
Interactions
Chlortetracycline (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementColestipol (HCl)DextranDigoxinGalantamineLithiumRiboflavin (Vitamin B2)Riboflavin interferes with the absorption and effectiveness of tetracyclines.RivastigmineSodium BicarbonateTheophyllineThiomersal These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Intereference with Urinary Urobilinogen Levels. Rise in Blood Urea, Eosinophils Count, SGPT, SGOT and Bilirubin.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Oint Store in a well closed container. Do not Freeze.
Warnings
Use chlortetracycline with caution (if contain tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Take appropriate measures if secondary infection occurs. Perform periodic lab evaluation of organ system (e.g. liver or kidney) in case of long term therapy. It should be used with caution during pregnancy or lactation.
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