Rosuvastatin

Rosuvastatin is a lipid regulating drug, belongs to statins. Rosuvastatin is a selective, competitive inhibitor of HMG-CoA reductase, an enzyme involved in the synthesis of cholesterol in the liver. Rosuvastatin is used in the treatment of primary hypercholesterolaemia, mixed dyslipidaemias or homozygous familial hypercholesterolaemia in patients who have not responded adequately to diet and other appropriate measures. Statins are more effective than other classes in lowering the LDL-cholesterol, they reduce coronary events, all cardiovascular events, and total mortality.


Adult Dose
Dose: 5 to 20 mg/day
Single Dose: 12 (12.5)
Frequency: As recommended.
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
Rosuvastatin Calcium is the derivative of Rosuvastatin. It is of Synthetic origin. . The Molecular Weight of Rosuvastatin is 1001.14.
Contraindications
Rosuvastatin is contraindicated in conditions like Liver diseases,Pregnancy,Lactation,Renal impairment,Hypersensitivity to any component of product.
Effects
Rosuvastatin produces potentially life-threatening effects which include Abdominal pain, Myalgia. which are responsible for the discontinuation of Rosuvastatin therapy.The symptomatic adverse reactions produced by Rosuvastatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Asthenia, Hypersensitivity, Pancreatitis.
Indications
Rosuvastatin is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipidaemia, and can also be given in adjunctive therapy as an alternative drug of choice in Hypertriglyceridaemia.
Interactions
No data regarding the interactions of Rosuvastatin was found.
Interfrence
Elevations of SGPT and SGOT Elevation in ALT or AST
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tabs Store at room temperature, Between 15°C-30°C. Protect from Moisture and Heat.
Warnings
Rosuvastatin therapy should be discontinued if markedly elevated creatinine kinase levels occur or myopathy is diagnosed or suspected. Rosuvastatin therapy should also be temporarily withheld in any patient with an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis.Should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease
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