Ezetimibe

Ezetimibe is a lipid regulating drug that inhibits the intestinal absorption of cholesterol. Ezetimibe is used as an adjunct to dietary measures and statin in primary and homozygous familial hypercholesterolaemia.


Adult Dose
Dose: 10 mg
Single Dose: 10 (10)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
Ezetimibe also known as Ezetna, Ezetna, Ezetna. . It is of Synthetic origin. . The Molecular Weight of Ezetimibe is 409.40.
Contraindications
Ezetimibe is contraindicated in conditions like Liver diseases,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Ezetimibe, which give rise to further complications include Thrombocytopenia, Hepatitis, Pancreatitis, Rhabdomyolysis, Muscular weakness, Chest pain, Choelithiasis, cholecystitis.Ezetimibe produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Ezetimibe therapy.The symptomatic adverse reactions produced by Ezetimibe are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Myalgia, Cough, Mild stomach pain, dizziness.
Indications
Ezetimibe is primarily indicated in conditions like Hypercholesterolaemia, Primary hypercholesterolaemia, and can also be given in adjunctive therapy as an alternative drug of choice in Homozygous familial hypercholesterolemia.
Interactions
Ezetimibe is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementSitosterolEzetimibe can reduce of amount of beta-sitosterol the body absorbs. This might decrease the effectiveness of beta-sitosterol.ModerateBe cautious with this combination. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevation of Creatine phosphokinase (CPK) with actual muscle damage in a much smaller proportion.
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Between 15°C-30°C. Protect from Sunlight, Moisture and Heat.
Warnings
Before using ezetimibe, tell your doctor if you are allergic to any drugs, or if you have: kidney disease, diabetes, overactive thyroid or if you use steroid medicine or hormones (including birth control pills). Keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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