Fondaparinux Sodium

Fondaparinux sodium is a synthetic pentasaccharide that inhibits activated factor X (clotting factor). Fondaparinux sodium is used for the prophylaxis of venous thromboemolism in patients undergoing major orthopaedic surgery of the legs.


Adult Dose
Dose: 2.5 mg
Single Dose: 2.5 (2.5)
Frequency: 24 hourly
Route: SC
Instructions: DVT Prophylaxis: After hemostasis is established, give the initial dose 6 to 8 h after surgery. Usual duration of therapy is 5 to 9 days (up to 11 days following hip or knee replacement surgery or up to 10 days following abdominal surgery). An extended prophylaxis course of up to 24 additional days (up to 32 days total) is recommended following hip fracture surgery.
Neonatal
Paedriatic
Characteristics
.
Contraindications
Fondaparinux Sodium is contraindicated in conditions like Bleeding,Renal impairment,Hypersensitivity to the drug,Bacterial endocarditis.
Effects
The symptomatic adverse reactions produced by Fondaparinux Sodium are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Fever, Constipation, Rashes, Pain, Anemia, Bleeding.
Indications
Fondaparinux Sodium is primarily indicated in conditions like Abdominal surgery prophylaxis, Deep vein thrombosis, Prophylaxis of deep vein thrombosis (in medical patients), Pulmonary embolism.
Interactions
No data regarding the interactions of Fondaparinux Sodium was found.
Interfrence
Elevation in ALT or ASTStool testingComplete blood cell count
Risks
Drug should not be given to patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature, . Protect from Moisture and Heat.
Warnings
Fondaparinux Sodium injection is not intended for intramuscular administration.Should be used with caution in patients with moderate renal impairment.Renal function should be assessed periodically in patients receiving Fondaparinux Sodium.The drug should be discontinued immediately in patients who develop severe renal impairment while on therapy.Fondaparinux Sodium Injection, like other anticoagulants, should be used with extreme caution in conditions with increased risk of hemorrhage, such as congenital or acquired bleeding disorders, active ulcerative and angiodysplastic gastrointestinal disease, hemorrhagic stroke, or shortly after brain, spinal, or ophthalmological surgery, or in patients treated concomitantly with platelet inhibitors.
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