Moexipril

Moexipril is an oral angiotensin-converting enzyme (ACE) inhibitor and is used to treat hypertension. Like quinapril and ramipril, the active metabolite is produced by deesterification from the prodrug. Moexiprilat (the deesterified form), is about 1000 times active than moexipril itself and antihypertensive activity entirely depends on this metabolite. Prolonged antihypertensive effects allow for once-daily dosing. The dosage range is halved in patients who are taking diuretics or who have renal impairment. It was approved by FDA on April 19, 1995.

Brands
Adult Dose
Dose: 7.5 mg
Single Dose: 7.5 (7.5)
Frequency: 24 hourly
Route: PO
Instructions: Initial dose: Should be taken 1 hour prior to meals.
Neonatal
Paedriatic
Characteristics
. It is strongly acidic drug.
Contraindications
Moexipril is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Moexipril, which give rise to further complications include Fever, Allergic reactions, Chest pain, Irregular heart beat.The signs and symptoms that are produced after the acute overdosage of Moexipril include fatigue, Dizziness, Fainting, Weakness.The symptomatic adverse reactions produced by Moexipril are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Anxiety, Palpitation, Rashes, Itching, Flushing, Chest pain.
Indications
Moexipril is primarily indicated in conditions like Hypertension.
Interactions
Moexipril is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAllopurinolAmiloride (HCl)Concurrent use may increase the blood pressure or heart rate.AspirinAspirin reduces the hypotensive effect of moexipril by inhibiting prostaglandin synthesis and thus suppressing the prostaglandin mediated hemodynamic effect of moexipril.ModerateMonitor blood pressure regularly and lowest therapeutic dose of aspirin should be used.AzathioprineConcurrent use may increase the blood pressure or heart rate.DigoxinConcurrent use may increase the blood pressure or heart rate.LithiumSpironolactoneConcurrent use may increase the blood pressure or heart rate. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased level of Blood urea nitrogen (BUN) concentrationsIncreased in serum creatinin
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Any form Store in a well closed container, at room temperature. Protect from Moisture and Heat.
Warnings
Use caution when driving as Moexipril may cause dizziness. Use alcohol cautiously as moexipril may further lower blood pressure. Donot use salt substitute or potassium supplements. Cautions should be taken in allergic patients.
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