Irbesartan

Irbesartan is an antihypertensive agent, belongs to angiotensin II receptor antagonists. The actions, uses and adverse effects are similar to those of losartan. Irbesartan is used either alone or in combination with other antihypertensive agents for the management of hypertension and other cardiovascular disorders.


Adult Dose
Dose: 150 mg
Single Dose: 150 (150)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
belongs to Angiotensin II Rantasonist. It belongs to Angiotensin-II receptor antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Irbesartan is 428.53.
Contraindications
Irbesartan is contraindicated in conditions like Pregnancy,Breast feeding.
Effects
The severe or irreversible adverse effects of Irbesartan, which give rise to further complications include Hyperkalemia, Impaired renal function, Myelgia.The symptomatic adverse reactions produced by Irbesartan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Tachycardia, Abdominal pain, Rashes, Confusion, Pharyngitis, Hypotension, Nausea and vomiting, Edema, Rhinitis, Chest pain, Angioedema, UTI, Confusion, dizziness.
Indications
Irbesartan is primarily indicated in conditions like Hypertension, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetic nephropathy, Heart failure, Renal disease in hypertensive type ii diabetes mellitus.
Interactions
Irbesartan is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementPotassium GlycerophosphateConcurrent use may cause too much potassium in the blood. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased level of Blood urea nitrogen (BUN) concentrationsIncreased in serum creatinin
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, Below 15°C. Protect from Moisture and Heat.
Warnings
Use with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertrophic cardiomyopathy.Monitor plasma-potassium concentration, particularly in elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.
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