Candesartan

Candesartan belongs to the unique class of antihyptensive agents called angiotensin II (AG II) receptor antagonists. The actions and uses are similar to those of Losartan.Its derivative Candesartan cilexetil is given orally in the treatment of hypertension, alone or in combination with other antihypertensive drugs. Candesartan like other angiotensin II receptor antagonist doesnot inhib Candesartan cilexetil the breakdown of bradykinins, and thus doesnot appear to cause persistant dry cough which complecates ACE inhibitor therapy, therefore Candesartan cilexetil is a useful alternative for patients who have to discontinue an ACE inhibitor because of persistant cough.


Adult Dose
Dose: 8 mg
Single Dose: 8 (8)
Frequency: 24 hourly
Route: PO
Instructions: Adjusted a/c to response. Max. 16 mg once daily.
Neonatal
Paedriatic
Characteristics
Candesartan Cilexetil is the derivative of Candesartan. It is of Synthetic origin. .
Contraindications
Candesartan is contraindicated in conditions like Cholestasis,Pregnancy,Breast feeding.
Effects
The symptomatic adverse reactions produced by Candesartan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Myalgia, Abdominal pain, Rashes, Arthralgia, Influenza like syndrome, Respiratory tract infections, Back pain.
Indications
Candesartan is primarily indicated in conditions like Hypertension, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetic nephropathy, Heart failure.
Interactions
Candesartan is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDiazoxideEnhanced hypotensive effect when Diazoxide given with Candesartan. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tabs Store in a well closed container, at room temperature, . Protect from Sunlight, Moisture and Heat.
Warnings
Hepatic and renal impairment; use with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertrophic cardiomyopathy.Monitor plasma-potassium concentration, particularly in elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.
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