HERCEPTIN

Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: As recommended.
Route: IV-Inf (over 90 min)
Instructions: Initially; followed by 2 mg/kg over 30 min at weekly intervals.

. It is of Natural origin. .

Trastuzumab is contraindicated in conditions like Breast feeding,Severe dyspnea at rest.

The severe or irreversible adverse effects of Trastuzumab, which give rise to further complications include Congestive heart failure, Cardiovascular toxicity, Ventricular dysfunction, Thromboembolic stroke.The symptomatic adverse reactions produced by Trastuzumab are more or less tolerable and if they become severe, they can be treated symptomatically, these include Inflammation, Dizziness, Headache, Anorexia, Diarrhea, Fever, Dyspnea, Insomnia, Chills, Rashes, Pain, Cough, Nausea and vomiting, Edema, Anemia, Leukopenia, Paresthesias, Infusion reactions, 1st dose, Infection.

Trastuzumab is primarily indicated in conditions like Metastatic breast cancer, Metastatic carcinoma of breast.

Trastuzumab is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAbciximabDoxorubicin (HCl)PaclitaxelWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Symptomatic heart failure History of hypertension Coronary artery disease Pregnancy CARDIOTOXICITY:Monitor cardiac function of all patients before and during treatment. Herceptin therapy should be used with caution in patients with known hypersensitivity to Trastuzumab, chinese Hamster ovary cell proteins, or any component of this product.