Interferon Alpha 2a

Interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The interferones bind to specific cell-surface receptors that initiate a series of intracellular events, induction of certain enzymes, inhibition of cell-proliferation, and enhancement of immune activities.The term "interferon alfa" actually refers to at least three compounds that only differ slightly in their amino acid sequence: interferon alfa-2a, interferon alfa-2b , and interferon alfa-n3. Interferon alfa-2a, highly purified protein produced by a recombinant DNA process. interferon alpha 2a is indicated in the treatment of a variety of tumours including hairy cell leukaemia, malignant melanoma, follicular lymphomaand AIDS related Kaposi`s sarcoma. Interferon alfa-2a was approved by the FDA in 1986.

Brands
UNIFERON UNIFERON 2A INFRON ALPHA INTEFEN CELL-AID CELL-AID CELL-AID CELL-AID PEGDAN PEGDAN INF-A LAIFULONG HIFERON HIFLEXIL INTER 2A INTER 2A INTER 2A BLAUFERON B
Adult Dose
Neonatal
Paedriatic
Characteristics
belongs to Protein(165 aminoacid). . The Molecular Weight of Interferon Alpha 2a is 19241.10.
Contraindications
Interferon Alpha 2a is contraindicated in conditions like Autoimmune hepatitis,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Interferon Alpha 2a, which give rise to further complications include Alopecia, Fever, Anemia, Anemia, Confusion, Drowsiness, Vasculitis, Neutropenia, Chest pain, Cough, Myalgia, Blurred vision, Myocardial infarction, Anemia, Anemia, Leukopenia, Diabetes mellitus.Interferon Alpha 2a produces potentially life-threatening effects which include Infection, Ischemic damage. which are responsible for the discontinuation of Interferon Alpha 2a therapy.The symptomatic adverse reactions produced by Interferon Alpha 2a are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Irritability, Anorexia, Insomnia, Dry mouth, Dry skin, Weight loss, Wheezing, Nausea, vomiting, sweating, and diarrhea (when ingested ), Dry mouth, Difficulty breathing, dizziness, Hives.
Indications
Interferon Alpha 2a is primarily indicated in conditions like AIDS-related kaposi sarcoma, Chronic hepatitis B infection, Chronic hepatitis C, Chronic myeloid leukaemia, Cutaneous t cell lymphoma, Hairy cell leukaemia.
Interactions
No data regarding the interactions of Interferon Alpha 2a was found.
Interfrence
Thyroid Function TestHematocrit Value
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Use cautiously in: thyroid disorders; bone marrow depression; hepatic, renal, or cardiac disease; pancreatitis; autoimmune disorders; pulmonary disorders; colitis; ophthalmic disorders; depression elderly patients pregnant or breastfeeding patients children younger than age 18.
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