Pioglitazone

Pioglitazone is a thiazolidinedione antidiabetic, reduces peripheral insulin resistance resulting in a reduction in blood-glucose concentration. Pioglitazone is used, either alone or in combination with metformin or sulphonylureas for the management of type II diabetes mellitus.


Brands
PIOZER PIOZER PIOZER GLIDEN GLIDEN GLIDEN ZOLID ZOLID ZOLID GLYROL GLYROL GLYROL GLITOS GLITOS GLITOS PIOKURE PIOKURE PIOKURE FANTASIA FANTASIA FANTASIA GLITASCOT GLITASCOT GLITASCOT DIACTO DIACTO DIACTO PIOZONE PIOZONE PIOZONE PION T PION T DIACTAL DIACTAL DIACTAL GLITLITE GLITLITE GLITLITE RANGON RANGON RANGON DIGOLITAZONE GLAPIO GLAPIO GLAPIO DOWGUT DOWGUT DOWGUT GLITER GLITER GLITER DIZONE DIZONE DIZONE PIOFIT PIOFIT POZE POZE POZE ZOLIGET ZOLIGET ZOLIGET ZOLIGET ZOLIGET ZOLID PLUS ZOLID PLUS PIOTONE GEM PIOTONE GEM PIOTONE PLUS PIOTONE PLUS PIOMET PIOMET PYCTOMET PYCTOMET PIOZER G PIOZER G PIOZER G PIOZER G PIOZER G PG MIN DIGLYTA DIGLYTA DOWGLIT DOWGLIT DOWGLIT PIOTONE PIOTONE PIOTONE PIOZON PIOZON PYCTOS PYCTOS PYCTOS ZEAL ZEAL ZEAL FANTASMIC PLUS FANTASMIC PLUS METPI METPI GLIO-P TAGOZER TAGOZER TAGOZER GLITZER GLITZER GLITZER FANTASMIC FANTASMIC GLITAMAP GLITAMAP PLUS GLITAMAP FORTE GLITAMAP FORTE PIORYL-M PIORYL-M PIOGLOTIN PIOGLOTIN PIOGLOTIN PIOGLOTIN PIOTEC PLUS PIOTEC PLUS LOTOPHAGE PLUS LOTOPHAGE PLUS ALROMET ALROMET ALROMET GLET GLET GLIBETIC FORTE LIGAZO LIGAZO LIGAZO METZON METZON NOLL PLUS NOLL PLUS PIOGET-M PIOGET-M PIOPRIDE PIOPRIDE PIORYL G PIORYL G PITAZ PITAZ PITAZ POZE-G POZE-G POZEMET POZEMET RAYFORMIN P RAYFORMIN P RAYPRIDE P RAYPRIDE P RAYPRIDE P INSIMAX INSIMAX PAGZAN PIOTEC PIOTEC PIOTEC TAGOZER-G TAGOZER-G TAGOZER-G TAZOGER-G PIOGET PIOGET PIOGET DIGLYTA PLUS GLIBETIC GLIBETIC GLIBETIC GLITOS PLUS GLITOS PLUS PIOBETIC PIOBETIC PIOBETIC PIOBETIC-G PIOBETIC-G PIOBETIC-G PIOZER-PLUS PIOZER-PLUS PIOZONE-PLUS PIOZONE-PLUS PIRE+4 GLIMULIN GLIMULIN GLIMULIN PIOCAN PREFAIR PREFAIR PREFAIR GLIGO-P
Adult Dose
Dose: 15 to 30 mg
Single Dose: 22 (22.5)
Frequency: 24 hourly
Route: PO
Instructions: Increased according to response to 45 mg once daily.
Neonatal
Paedriatic
Characteristics
Pioglitazone HCL is the derivative of Pioglitazone. It is of Synthetic origin and belongs to Thiazolidinedione. .
Contraindications
Pioglitazone is contraindicated in conditions like Cardiac failure,Hepatic impairment,Hypersensitivity to the drug,In combination with insulin,History of cardiac failure.
Effects
The severe or irreversible adverse effects of Pioglitazone, which give rise to further complications include Jaundice.The symptomatic adverse reactions produced by Pioglitazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Myalgia, Pharyngitis, Sinusitis.
Indications
Pioglitazone is primarily indicated in conditions like Diabetes mellitus type-ii, Softening and dilatation of cervix before mechanical cervical dilatation, Type II diabetes mellitus.
Interactions
Pioglitazone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAescinBaclofenBudesonideCarbamazepineClozapineDiazoxideGemfibrozilGinkgo Biloba ExtractGinseng ExtractLovastatinOctreotide (Acetate)OlanzapinePhenobarbitonePhenytoin (Na)RifabutinRisperidoneSotalol (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Hematocrit Value Elevaions in creatinine phosphokinase levels
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Monitor liver function (Rare reports of liver dysfunction; monitor liver function before treatment, then every 2 months for 12 months and periodically thereafter; ask patient to immediately get medical attention if symptoms such as nausea, vomiting, abdominal pain, fatigue and dark urine develop; discontinue if jaundice occurs. Cardiovascular disease (risk of heart failure)
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