Methotrimeprazine(HCl)

Methotrimeprazine(HCl) is phenothiazine with actions and pharmacological properties similar to that of both clorpromazine and promethazine. Methotrimeprazine(HCl) is used intramuscularly (IM), in the treatment of various psychoses including schizopherenia, as an adjunct to analgesics in the management of severe terminal pain. Methotrimeprazine (HCl) is also used as a premedicant and is given prior to surgical procedures.

Brands
Adult Dose
Dose: 6 to 25 mg/day
Single Dose: 16 (15.5)
Frequency: As recommended.
Route: PO
Instructions: For minor conditions: should be given in 3 divided doses.Increase the dosage until the optimum level has been reached.
Neonatal
Paedriatic
Dose: 100 to 0 mg
Single Dose: 50 (50)
Frequency: As recommended.
Route: IV or S/C
Instructions:
Characteristics
Methotrimeprazine(HCl) also known as Levomepromazine[HCl]. . It is of Synthetic origin and belongs to Phenothiazine. . The Molecular Weight of Methotrimeprazine(HCl) is 365.00. Its pKa is 9.15.
Contraindications
Methotrimeprazine(HCl) is contraindicated in conditions like Bone marrow depression,Coma,Heart disease,Close-angle glaucoma.
Effects
The severe or irreversible adverse effects of Methotrimeprazine(HCl), which give rise to further complications include Tardive dyskinesia, Paralytic ileus, Seizures, Lens opacities, Maculopathy, Respiratory distress.Methotrimeprazine(HCl) produces potentially life-threatening effects which include Agranulocytosis, Malignant neuroplastic syndrome. which are responsible for the discontinuation of Methotrimeprazine(HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Methotrimeprazine(HCl) include Hypotension, Tachycardia, ECG alterations, Drowsiness, Hypothermia, Ventricular arrhythmias, Severe extrapyramidal dyskinesias, Loss of conciousness.The symptomatic adverse reactions produced by Methotrimeprazine(HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Sedation, Photosensitivity, Parkinsonism, Hypotension, Weight gain, Asthenia, Contact dermatitis, Erythematous rash.
Indications
Methotrimeprazine(HCl) is primarily indicated in conditions like Anxiety, Moderate to severe pain, Psychosis, Schizophrenia.
Interactions
No data regarding the interactions of Methotrimeprazine(HCl) was found.
Interfrence
Estimation Tests of serum and urinary Cortisol
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, . Protect from Sunlight.
Warnings
Methotrimeprazine should be used in low initial dose. Monitor pulse and blood pressure until dosage requirements and responses are stabilized in elderly and debilitated patients.
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