COMBINOL-D COMBINOL DM COUGH ANGLOMONIA ANGLOMONIA ANGLOMONIA APITON ALCOF E ALCOF D TORANT TORANT TORANT SYREX FENRAM FENRAM FENRAM FENRAM TYLADOL-CF BIOCOUGH BIOCOUGH BIOCOUGH PULMONOL PULMONOL PULMONOL EPINOL-CF EPINOL-CF EPINOL-E EPINOL-DM EPINOL-DM DOSACOREX-D COFSONIL COFSONIL PABCOL PABCOL PABCOL TYLOL CF CAMCOUGH CAMCOUGH CAMCOUGH PULMOBEX HAMZIVIL HAMZIVIL FEROCOL-D BRONOCHOL BRONOCHOL EPONIUM EPONIUM COCIL CHLORPHENIRAMINE MALEATE HISTAMOL-D HISTAMOL-D AMCODRIN AMCODRIN AMCODRIN HISTAMOL HISTAMOL EPLACIN CF PANADOL-CF PIRITON EXPECTORANT PIRITON CHLORPHENIRAMINE FENAMINE ZODEC ZODEC COUGHSODEX TRIAD COLD KARMOL-NEO KARMOL CF EXPETUS HISTOM ALLERVIL EXCOLD EXCOLD EXCOLD CHLORPHENIRAMINE CHLORPHENIRAMINE CHLORPHENIRAMINE CHLORPHENIRAMINE J.COUGH J.COUGH J.COUGH RHINOL CHLOROPHENIRAMINE MALEATE IRZAPOLE CF ISCHEMOL LIZRIN LIZRIN LIZRIN CHLORPHENIRAMINE CHLORPHENIRAMINE CHLORPHENIRAMINE METRAFED METRAFED AMCOF AMCOF PHEMIN PHEMIN PHEMIN AMOLE POWER GLYCODIN GLYCODIN GLYCODIN AMMONIUM CHLORIDE AMMONIUM CHLORIDE AMMONIUM CHLORIDE NOSCABINE AMMOTUS ALLERMINE ALLERMINE ALLERMINE UNIREX-D UNIREX-D BRONCODYL-D BRONCODYL-D AMCHLO AMCHLO ALLERGON AXADOL PLUS ALLERGEX REFCOF REFCOF REFCOF LOLRPHINE TRIAMINIC COLD & ALLERGY SANCOS SANCOS TRIAMINIC FLUE,COUGH ORODIL ORODIL CHLORPHENIRAMINE NENGESIC-CF CHLORPHENIRAMINE CHLORPHENIRAMINE CHLORPHENIRAMINE PHENAMINE PHOLTUSS PHOLTUSS CHLORPHENIRAMINE COSOME EPHAZOL-C AMMODRYL AMMODRYL ALLERPHENE ALLERPHENE ALLERPHENE ALLERPHENE ALLERPHENE AMCHOL AMCHOL AMCHOL RELTUS-DM RELTUS C&F RELTUS C&F RELTUS C&F PLUS RELTUS EXPECTORANT COREX-D COREX-D CHLORPHENIRAMINE TRICOS TRICOS SEPTEM PACIFICS J&J PACIFICS J&J NOVATUS BUCKLEYS JACK & JILL BUCKLEYS JACK & JILL FEMIDOL BENICAL AMMONICA AMMONICA AMMONICA TYNO COUGH TYNO COUGH TYNO-SF COUGH DEKUF ZICOL TEXCOL PLUS ABENOL PLUS CHLORPHENIRAMINE C.C. DON-CF SORAX SPENSID SANSI SENSI E PULMAX PULMAX SEMOCOF SEMOCOF SEMOCOF ROYACOF CHLORPHENIRAMINE PHENERMIN PHENERMIN PHENERMIN CHLORPHENIRAMINE PEDROL-CF PEDROL TOTAL PECTUS SUDOMIN COLDREX AMONI CHLORTAB CHLORTAB CHLORPHENIRAMINE ZECOF ZECOF ZECOF KASAMINE KASAMINE CHLORPHENIRAMINE TEMPRAMINE TEMPRAMINE BRONEX BABYNOL COUGHSOL VIRITON VIODOL CF BENAFED CF AMRON AMRON AMRON CONIL CONIL CONIL AMIDOL AMIDOL TUSSEX AMYDRINE AMYDRINE DEECHLORIDE DEECHLORIDE DEECHLORIDE DEEMINE DELMON DELMOL-CF ENMOL ENMOL ENMOL COUGHNOL NOVODYL FREECOS FREECOS FREECOS MB-COF LISKOZ LISKOZ AMCORIDE AMCORIDE AMCORIDE LISKODYL LISKODYL HISTAGIC HISTAGIC HISTAGIC CHLORPHENIRAMINE CHLORPHENIRAMINE CHLORPHENIRAMINE REGODOL PLUS REGODOL CF REGOCOF REGOCOF REGOCOF AMONIL AMONIL KOFKODIL C.P.M.MALATE HISTALON HISTALON REMISOLE REMISOLE REMISOLE KOFNIL KOFNIL KOFNIL-D KOFNIL-D BABY RHINOCOL PHENIR RESIDOL-CF COFRADIN COFRADIN COFRADIN CHLORPHENIRAMINE MALEATE CEPIAM CEPIAM EROCOF P EROCOF P EROCOF P KEMODRYL PLUS STAITON STAITON STAITON EROCOF-A EROCOF-A EROCOF-A COFSED COFSED CHLORPHENIRAMINE CHLORPHENIRAMINE CHLORPHENIRAMINE CHLORPHENIRAMINE COFCOLD DM HARITON NIRMINE COUGH-FLU COUGH-FLU VISCODIN PHOLCODINE COMPOUND AMONIUM CHLORIDE AMONIUM CHLORIDE CHLORPHENIRAMINE MALEATE COFCINA-D COFCINA-D BARITON BARITON UNIHIST MULTI-ACTION MULTI-ACTION AVALON AVALON AVALON FLU CHLORPHENIRAMINE CHLORPHENIRAMINE FEVERAMIN-D PALADIN-E PALADIN-E ZANODRIL ZANODRIL ZANODRIL ZONCHLOPHEN ZONCHLOPHEN TRACODIL DM TRACODIL TRACODIL TRACODIL RESMIN RESMIN RESMIN RESMIN AMMORIDE AMMORIDE AMMORIDE REPHENIRAMINE REPHENIRAMINE REPHENIRAMINE REPHENIRAMINE CAMPOL PLUS COFCOL COFCOL COFCOL RONDEC RONDEC OMNIDOL ROVIDOL AMRID AMRID AMRID CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE MALEATE EXPECTO EXPECTO EXPECTO FANIDOL WYLADOL-CF CHLOFAMIN ANIMOL ANIMOL ANIMOL ALPHEM DISOL DENOL-DM KOF-S BRONCODYL BRONCODYL CAFIMOL CF CHLOR SYNADRYL HANMOL CF CHLORILEX CHLORILEX AMORADE ALMUNOL COLEN CHILPOL TOTAL SUSPENTION AZIDOL CHILPOL CF COUGH CARE COUGH CARE COUGH CARE ALLERGYCARE ALLERGYCARE JETAMOL CF COUGHTIN EXPECTORANT SYPRITON DHLORAMINE COFTA EXPECTORANT COFTA EXPECTORANT COFTA EXPECTORANT ACTIRON CF

Dose: 10 to 20 mg
Single Dose: 15 (15)
Frequency: 24 hourly
Route: IV,IM,SC
Instructions: Slow IV over a period of 1 minute. total dose should not exceed 40 mg.

Dose: 0.1 mg/kg
Single Dose: 0.1 (0.1)
Frequency: 8 hourly
Route: oral
Instructions:

Dose: 0.25 to 0.5 mg/kg
Single Dose: 0.38 (0.375)
Frequency: 24 hourly
Route: Intra Muscular
Instructions:

Chlorpheniramine (Maleate) also known as Chlorphenamine Maleate. . It is of Synthetic origin and belongs to Alkylamine. It belongs to H1-antagonist pharmacological group on the basis of mechanism of action. The Molecular Weight of Chlorpheniramine (Maleate) is 274.88. Its pKa is 9.2.

Chlorpheniramine (Maleate) is contraindicated in conditions like Hypersensitivity.

The severe or irreversible adverse effects of Chlorpheniramine (Maleate), which give rise to further complications include Sinus tachycardia, Jaundice, Jaundice, Seizures, Hypertension, CNS stimulation.Chlorpheniramine (Maleate) produces potentially life-threatening effects which include Bone marrow suppression. which are responsible for the discontinuation of Chlorpheniramine (Maleate) therapy.The signs and symptoms that are produced after the acute overdosage of Chlorpheniramine (Maleate) include Hypotension, Convulsions, Coma, Urinary retention, Unconsciousness, Fever, Dryness of mucous, Flushing membrane, Pupillary dilatation.The symptomatic adverse reactions produced by Chlorpheniramine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Fatigue, Nausea, Vomiting, Restlessness, Palpitation, Constipation, Abdominal pain, Dry mouth, Blurred vision, Sedation, Polyuria, Facial dyskinesias, Blood dyscrasias, Xerostomia, Dry mouth.

Chlorpheniramine (Maleate) is primarily indicated in conditions like Acute urticaria, Advanced ovarian cancer, Allergic conjunctivitis, Angiooedema, Atopic dermatitis, Chronic urticaria, Emergency treatment of anaphylactic reaction, Seasonal allergic rhinitis, Transcervical operative procedures in first trimester, and can also be given in adjunctive therapy as an alternative drug of choice in Common cold.

Chlorpheniramine (Maleate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholMajorAstemizoleConcomitant use of chlorpheniramine maleate and astemizole increase the risk of arrythmias.MajorContraindicatedAzatadine (Maleate)Diclofenac (K)It increases effects of chlotpheniramine. as it is is a CYP3A4 inhibitorDoxycyclineIt increases effects of chlotpheniramine. as it is is a CYP3A4 inhibitorFosphenytoinImatinib MesylateIt increases effects of chlotpheniramine. as it is is a CYP3A4 inhibitorOxymorphoneCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.ModerateDuring concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.ParegoricCentral nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.ModerateDuring concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.Phenytoin (Na)QuinidineIt increases effects of chlotpheniramine. as it is is a CYP3A4 inhibitorTerfenadineConcomitant use of chlorpheniramine maleate and terfenadine increase the risk of palpitation.Verapamil (HCl)It increases effects of chlotpheniramine. as it is is a CYP3A4 inhibitor These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Syrup Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight and Moisture. Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.

Chlorpheniramine should be used with caution in bone marrow depression. Patients should observe caution while driving or performing other task requiring alertness because it may cause drowsiness. It should be used with caution in patients with urinary retention, history of bronchial asthma, hyperthyroidism, cardiovascular or liver disease. It should be used with caution in person with acute or chronic respiratory impairment, especially in children. Do not administer subcutaneously because irritation or lesion may occur.