Chlorzoxazone

Chlorzoxazone is a centrally acting skeletal muscle relaxant with sedative properties. Chlorzoxazone is used as an adjunct in the symptomatic treatment of painful muscle spasm. It inhibits muscle spasm by exerting its effect at the level of the spinal cord and subcortical area of the brain. Chlorzoxazone is usually given with analgesics in compound preparations.

Brands
ZOXA-Z DELZONE
Adult Dose
Dose: 250 to 750 mg
Single Dose: 500 (500)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Chlorzoxazone is 169.60.
Contraindications
Chlorzoxazone is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Chlorzoxazone, which give rise to further complications include Hypotension, Hypotension, Respiratory depression.Chlorzoxazone produces potentially life-threatening effects which include Hepatotoxicity. which are responsible for the discontinuation of Chlorzoxazone therapy.The signs and symptoms that are produced after the acute overdosage of Chlorzoxazone include Drowsiness, Dizziness, Headache, GI disturbances, Malaise.The symptomatic adverse reactions produced by Chlorzoxazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashes, Sedation, Skin rashes.
Indications
Chlorzoxazone is primarily indicated in conditions like Muscular spasm.
Interactions
No data regarding the interactions of Chlorzoxazone was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, . Protect from Sunlight, Moisture and Heat.
Warnings
Chlorzoxazone should not be given to patients with impaired liver function and should be discontinued if signs of liver toxicity appear. Patient should be advised to report the doctor if any sign or symptom of possible liver toxicity appear such as fever, rash, jaundice, dark urine, anorexia, nausea, vomiting or right upper quadrant pain. The drug should only be used in pregnancy if clearly needed. Patients should observe caution while driving or performing other tasks requiring alertness. The urine of the patient taking chlorzoxazone may be coloured orange or reddish-purple by a phenolic metabolite.
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