Co-Amoxiclav

Co-Amoxiclav is a combined preparation of amoxicillin with beta-lactamase inhibitor clavulanic acid. Amoxicillin is a beta-lactam antibiotic, a derivative of ampicillin with a similar bacterial spectrum, but Co-Amoxiclav is inactivated by beta-lactamases (enzymes produced by some bacteria). Clavulanic acid itself has no significant antibacterial activity, but by inactivating beta-lactamases, it makes the combination active against beta-lactamase-producing bacteria that are resistance to amoxicillin.

Brands
Adult Dose
Dose: 375 to 652 mg
Single Dose: 510 (513.5)
Frequency: 8 hourly
Route: PO
Instructions: Doses vary according to indication. Use 1g/dose in severe infections. To minimize potential gastrointestinal intolerance and to optimize absorption of drug, administer at the start of a meal
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin and belongs to Amoxycillin+Clavulanic Acid. .
Contraindications
Co-Amoxiclav is contraindicated in conditions like Penicillin hypersensitivity.
Effects
The severe or irreversible adverse effects of Co-Amoxiclav, which give rise to further complications include Convulsions, Hepatitis, Cholestatic jaundice, Stevens johnson syndrome, Epidermal necrolysis, Angioedema, Erythema multiforme, Exfoliative dermatitis, Interstitial nephritis, Oedema, Urticarial rash, Erythematous rash, Reversible leucopenia, Reversible thrombocytopenia, Reversible hemolytic anemia.Co-Amoxiclav produces potentially life-threatening effects which include Anaphylaxis, Hypersensitivity vasculitis, Severe sickness like syndrome. which are responsible for the discontinuation of Co-Amoxiclav therapy.The signs and symptoms that are produced after the acute overdosage of Co-Amoxiclav include Electrolyte disturbances, Fluid disturbance.The symptomatic adverse reactions produced by Co-Amoxiclav are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Colitis, Indigestion, Candidiasis, Nausea and vomiting, Hyperactivity.
Indications
Co-Amoxiclav is primarily indicated in conditions like Dental infections, Hyperlipidaemias, Lower respiratory tract infections, Overdosage with opioids, Soft tissue and skin infections, Surgical prophylaxis, Upper respiratory tract infections, Urinary tract infection.
Interactions
No data regarding the interactions of Co-Amoxiclav was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
It should be used with caution in patients with hepatic dysfunction, patients on anticoagulant therapy and in combination with broad spectrum antibiotics. Its use should be avoided in pregnancy.
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