Chloroquine is a synthetic 4-aminoquinoline compound. It has antiprotozoal and anti-inflammatory properties. Chloroquine is formulated as phosphate salt for oral use and as hydrochloride for parentral use. Chloroquine is effective for the suppression and treatment of malaria and as an antiinflammatory in the treatment of rheumatoid arthritis. It is also used to treat amebiasis.
Effects
The severe or irreversible adverse effects of Chloroquine, which give rise to further complications include Fever, Pruritis, Seizures, Retinopathy, Agitation, Blurred vision, Gastrointestinal upset.Chloroquine produces potentially life-threatening effects which include Convulsions, Postural hypotension, Aplastic Anemia, Cardiopulmonary arrest, CVS depression, Psychosis, Aplastic anemia, Postural hypotension. which are responsible for the discontinuation of Chloroquine therapy.The signs and symptoms that are produced after the acute overdosage of Chloroquine include Nausea, Vomiting, Convulsions, Coma, Drowsiness, Headache, Dysphagia, Cardiopulmonary arrest, Tremor, Fatal poisoning, Hoarseness, Nausea & vomiting, Visual distrubances, Weakness, Dyspnea.The symptomatic adverse reactions produced by Chloroquine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Abdominal pain, Blurred vision, Rashes, Urticaria, Itching, Hair loss, Skin eruptions, Bleaching of hair, Skin eruptions, Loss of appetite, dizziness.