Zoledronic Acid

A bisphosphonate, which affects bone metabolism. It is adsorbed onto hydroxyapetite cryastals in bone , slowing both their rate of growth and dissolution, and therefore reducing the rate of bone turnover. It reduces bone damage in advanced malignancies involving bone (with calcium and vitamin D supplement), it is also given in hypercalcemia of malignancy.

Brands
ZOMETA ACLASTA ZOLDIC ZOLDRIA EDONAX EDONAX ZOLEDRON KEDRONICO
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Biphosphonate. .
Contraindications
Zoledronic Acid is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Zoledronic Acid, which give rise to further complications include Anemia, Bradycardia, Renal impairment, Increased creatinine, Increase in blood urea, Hypoglycemia.The symptomatic adverse reactions produced by Zoledronic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Headache, Fatigue, Nausea, Vomiting, Anorexia, Fever, Myalgia, Bone pain, Arthralgia, Taste perversion, Conjunctivitis.
Indications
Zoledronic Acid is primarily indicated in conditions like Hypercalcaemia of malignancy, Reduction of bone damage, Skeletal disorder prevention in bone malignancies, Tumour induced hypercalcaemia.
Interactions
No data regarding the interactions of Zoledronic Acid was found.
Interfrence
Risks
Drug should not be given to Paediatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
No data regarding the Warnings/Precuations of Zoledronic Acid is available.
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