Dose: 3.57 to 7.142 mg/kg
Single Dose: 5.4 (5.356)
Frequency: 24 hourly
Route: PO
Instructions: At bed time

Dose: 0.08 mg/kg/min
Single Dose: 0.08 (0.08)
Frequency: 24 hourly
Route: Infusion
Instructions: As required

Dose: 0.08 mg/kg.min
Single Dose: 0.08 (0.08)
Frequency: As recommended.
Route: IV Infusion
Instructions: As Required, dose may be gradually increased

Chlormethiazole (Edisylate) also known as Clomethiazole (Edisylate). . It is of Synthetic origin and belongs to Thiazole. It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action. The Molecular Weight of Chlormethiazole (Edisylate) is 161.70. Its pKa is 3.3.

Chlormethiazole (Edisylate) is contraindicated in conditions like Pulmonary insufficiency.

The severe or irreversible adverse effects of Chlormethiazole (Edisylate), which give rise to further complications include Dependency.Chlormethiazole (Edisylate) produces potentially life-threatening effects which include Respiratory arrest, Anaphylactic reactions. which are responsible for the discontinuation of Chlormethiazole (Edisylate) therapy.The signs and symptoms that are produced after the acute overdosage of Chlormethiazole (Edisylate) include Respiratory depression.The symptomatic adverse reactions produced by Chlormethiazole (Edisylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Skin rashesX, Thrombophlebitis, Sneezing, Conjunctival irritation, Nasal congestion.

'Chlormethiazole (Edisylate) is primarily indicated in conditions like Agitation, Alcohol withdrawal, Delirium tremens, Insomnia, Pre-eclamptic toxaemia, Regional anaesthesia, Severe insomnia (short-term use), Status epilepticus, Urinary frequency, and can also be given in adjunctive therapy as an alternative drug of choice in Muscle relaxation, Parkinson''s disease.'

No data regarding the interactions of Chlormethiazole (Edisylate) was found.

Increase activity of glycine

Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Cap, IV Inf, Oral soln Store in refrigerator.

Patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. Avoid use in patient with acute pulmonary insufficiency. Chlormethiazole should be used with caution in patients with chronic pulmonary insufficiency, renal (kidney), liver, cerebral or cardiac disease and respiratory disease.