Imatinib Mesylate

Imatinib Mesylate is a protein-tyrosine kinase inhibitor, an antineoplastic (anticancer) drug. Imatinib Mesylate is licensed for the treatment of chronic myeloid leukaemia (CML) in chronic phase where first-line therapy is failed to give adequate response. It should be used only under specialist supervision.

Brands
GLIVEC GLIVEC GLIVEC GLIVEC
Adult Dose
Dose: 400 mg
Single Dose: 400 (400)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Imatinib Mesylate is 589.70.
Contraindications
Imatinib Mesylate is contraindicated in conditions like Breast feeding.
Effects
The severe or irreversible adverse effects of Imatinib Mesylate, which give rise to further complications include Fluid retension, Erythema multiforme, Acute renal failure, Oedema, Erythema multiforme.Imatinib Mesylate produces potentially life-threatening effects which include Thrombocytopenia, Neutropenia. which are responsible for the discontinuation of Imatinib Mesylate therapy.The symptomatic adverse reactions produced by Imatinib Mesylate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Anorexia, Skin reactions, Insomnia, Dry mouth, Muscle cramps, Pyrexia, Lacrimation, Dry cough, Taste disturbances, Paresthesias, GI disturbance, Ulceration, CNS disturbances, Dry mouth, GI bleeding, influenza, dizziness, Dyspnoea.
Indications
Imatinib Mesylate is primarily indicated in conditions like Chronic myeloid leukaemia, Gastrointestinal stromal tumour, Hypertension.
Interactions
Imatinib Mesylate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementChlorpheniramine (Maleate)It increases effects of chlotpheniramine. as it is is a CYP3A4 inhibitorVORICONAZOLEVoriconazole may increase the serum concentration of imatinib by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Liver Function Test (LFT) Increased Alkaline Phosphatase LevelsElevation in ALT or AST
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Imatinib should be used with caution in pregnancy (avoid unless potential benefit outweighs risk).It should be taken with food & a large glass of water to minimize gastrointestinal irritation.
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