Chlordiazepoxide (HCl)

Chlordiazepoxide is a 1,4-benzodiazipine. A substituent in the 7th position such as halogen or a nitro group is required for its sedative, and hypnotic activity. Benzdiazipines are the most widely used anxiolytic drugs. The benzodiazipines are more effective and safer. They have largely replaced barbiturates and meprobamates in the treatment of anxiety.

Brands
ELENIUM ELENIUM ZEPOX LIBRAX LIBERAN CHLOBRIUM CHLOBRIUM ALIUM ELIRAX CHLORDIAZEPOXIDE
Adult Dose
Dose: 5 to 100 mg
Single Dose: 52 (52.5)
Frequency: 8 hourly
Route: PO
Instructions: Frequency may be increased upto 4 times/day if needed.
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 5 to 10 mg
Single Dose: 7.5 (7.5)
Frequency: 12 hourly
Route:
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Benzodiazepines. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Benzodiazepine pharmacological group.The Molecular Weight of Chlordiazepoxide (HCl) is 336.20. It is strongly acidic drug, 5.50% solution of the drug is isotonic and Its pKa is 4.6.
Contraindications
Chlordiazepoxide (HCl) is contraindicated in conditions like Depression,Pulmonary insufficiency,Respiratory depression.
Effects
The severe or irreversible adverse effects of Chlordiazepoxide (HCl), which give rise to further complications include Psychological impairment, Cerebral atrophy, Psychomotor performance impairment.Chlordiazepoxide (HCl) produces potentially life-threatening effects which include Hemolytic anemia, Hypoplastic Anemia. which are responsible for the discontinuation of Chlordiazepoxide (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Chlordiazepoxide (HCl) include Coma, Drowsiness, Confusion, Ataxia, Sedation.The symptomatic adverse reactions produced by Chlordiazepoxide (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin reactions, Aggression, Dependence.
Indications
Chlordiazepoxide (HCl) is primarily indicated in conditions like Acute alcohol withdrawal, Adjunct in acute alcohol withdrawal, Adjunt in acute alcohol withdrawal, Anxiety, Insomnia, Muscular spasm, Premedication in anaesthesia, Psychosomatic disorders, Suppression of transplant rejection, and can also be given in adjunctive therapy as an alternative drug of choice in Alcohol withdrawal.
Interactions
Chlordiazepoxide (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAluminium Hydroxide and OxideAtropine (Sulphate)Cimetidine (HCl)Human InsulinInsulin LisproIprindoleTheoretical potential for CHLORDIAZEPOXIDE increasing the SEDATIVE effect of IPRINDOLE.ModerateIproniazid PhosphateInfrequent reports of CHLORDIAZEPOXIDE increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID. Metoclopramide (HCl)MorphinePhenytoin (Na)VORICONAZOLEVoriconazole may increase the serum concentration of chlordiazepoxide by decreasing its metabolism. Monitor for chlordiazepoxide toxicity if voriconazole is initiated or dose increased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
Warnings
Perform periodic blood counts and liver function tests during long term therapy of chlordiazepoxide. It should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).
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