CHLORMAX ECONOCHLOR CHLORAMPHENICOL CHLOROPTIC DOSACHLOR CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAX CHLORAX CHLOROFEN EPOPHENICOL EPOPHENICOL EPOPHENICOL EPOPHENICOL EPOPHENICOL EPOPHENICOL CHLORAMPHENICOL VASOCHLOR DEXACHLOR GEOCLOR CHLORAMPHENICOL FENOPTIC LORAM IRZAPHENICOL IRZAPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL FLUOROBIOPTAL ANTIBIOPTAL INVOCLOR INVOCLOR CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL NOVOPHENICOL NOVOPHENICOL NOVOPHENICOL NOVOPHENICOL NOVOPHENICOL CHLORAMPHENICOL MEDIKUF CHLOROMED VITACHLOR MEDICHLOR PLUS MEDIDEX-C COMYCETIN COMYCETIN SPERSANICOL SPERSADEXOLINE SPERSADEX COMPOUND LEVOCORT LEVOCORT OMYCETIN OMYCETIN OMYCETIN SIFICETINA SIFICETINA XANTERVIT M-PHENICOL M-PHENICOL CHLORAMPHENICOL NEO-PHENICOL H.C. CHLORMIC NEOBREX NEOBREX NEO-PHENICOL NEO-PHENICOL NEO-PHENICOL NEO-PHENICOL CHLOROMAX CODOHYST PHENICOL PHENICOL CHLOROMYCETIN HC CHLOROMYCETIN PALMITATE CHLOROMYCETIN FORTE CHLOROMYCETIN CHLOROMYCETIN CHLOROMYCETIN CLORAMIDINA H CLORAMIDINA COMPLEX CLORAMIDINA CLORAMIDINA PLIPHENICOL CHLOROPHENICOL CHLOROPHENICOL CHLOROPHENICOL SANTOCHLOR SANTOCHLOR DEXOPTIC-C SEMOFENICOL SEMOFENICOL FENICOL FENICOL CHLORAMPHENICOL ORBACHLOR CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL CHLORAMPHENICOL ELKOPHENICOL S CHLORAMPHENICOL PHENICHLOR CHLORDEX MB-CHLOR MB-CHLOR MB-CHLOR MAVICHLOR LISKOMYCETIN CHLORAMPHENICOL REMICOL CHLORAMPHENICOL PREDNICOL OPTACHLOR OPTACHLOR METHACHLOR METHACHLOR BIOSTAT CHLORAMPHENICOL CHLORAMPHENICOL REXAPHENICOL PREDNISYNTH SCHAZOMYCETIN DEXACOR OCUCHLOR OCUPRED FORTE OCUPRED-CHLOR EROPHENICOL EROPHENICOL MONCOL CHLORAMPHENICAL CHLORAMPHENICAL CHLORAMPHENICAL CHLOROGEN CHLOROGEN CHLOROGEN PREDNI-C MONOPHENICOL MANOPHENICOL MANOPHENICOL UNIPHENICOL CHLORAMPHENICOL OPHTH-CHLOR EYCHLOR EYCHLOR DECACHLOR MEDCLOR VEGACHLOR VECHLOR ZALOMYCETIN ZALOMYCETIN BIOMYCINE ORICOL CHLORAMPHENICOL CHLORAMPHENICOL O-MYCETIN BENTHAPHEN KLORECAL DILOCAL PREDSIN LEXICOL VI-CHLOR OPCHLOR KOHSCLOR KOHSCLOR

Dose: 0.5 %w/v
Single Dose: 0.5 (0.5)
Frequency: 2 hourly
Route: Ophthalmic
Instructions:

Dose: 12.5 to 25 mg/kg
Single Dose: 19 (18.75)
Frequency: 6 hourly
Route: Intravenous
Instructions:

Dose: 12.5 to 25 mg/kg
Single Dose: 19 (18.75)
Frequency: 6 hourly
Route: Intra Venous
Instructions: -

Chloramphenicol Palmitat is the derivative of Chloramphenicol. It is of Semi Synthetic origin and belongs to Nitrophyenyl acetamide. It belongs to Peptidyl transferase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Chloramphenicol is 323.10. It is weakly acidic drug, 6.83% solution of the drug is isotonic and Its pKa is 5.5.

Chloramphenicol is contraindicated in conditions like Hypersensitivity.

The severe or irreversible adverse effects of Chloramphenicol, which give rise to further complications include Encephalopathy, Pseudomembranous colitis, Urticaria, Thrombocytopenia, Hepatitis, Aplastic anemia, Hemolytic anemia, Aplastic anemia, Hemolytic anemia, Ototoxicity, Peripheral neuropathy, Optic neuritis, Hemolytic reactions, Interstitial nephritis, Hemolytic anemia, Aplastic anemia, Hair growth depression, Physical growth depression.Chloramphenicol produces potentially life-threatening effects which include Bone marrow suppression, Grey baby syndrome, Anaphylaxis. which are responsible for the discontinuation of Chloramphenicol therapy.The signs and symptoms that are produced after the acute overdosage of Chloramphenicol include Grey baby syndrome.The symptomatic adverse reactions produced by Chloramphenicol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Maculopapular rash, Stomatitis, Confusion, Pruritus, Depression, Glossitis, Delirium, Vision disturbances, Confusion, Transient stinging, Typhoid, Salmonella infection.

'Chloramphenicol is primarily indicated in conditions like Acromegaly, Acute epiglottitis, Anaerobic infections, Bacterial infections, Blepharitis, Brain abscesses, Brucellosis, Cellulitis, Corneal ulcers, Intraocular infections, Iron deficiency anaemia, Keratoconjuctivitis sicca, Life threatning infections, Meningitis, Peritonitis, Plague, Psittacosis, Q Fever, Septicaemia, Spotted fever, Tularemia, Typhoid, and can also be given in adjunctive therapy as an alternative drug of choice in Enteritis, Gangrene, Haemophilia, Influenza, Whipple''s disease.'

Chloramphenicol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmoxicillinAmpicillinAscorbic AcidAzlocillin (Na)BacampicillinBenzathine PenicillinCarbenicillin (Na)Chloramphenicol inhibit the effect of carbenicillin by inhibiting cellular protein synthesis and change bacteria into static one thus reducing the effectiveness of carbenicillin.ModerateCombination must be avoided. If necessary then carbenicillin administered several hours before chloramphenicol and closely observed the antimicrobial efficacy.ChlorpropamideChloramphenicol reduces the hepatic clearence of chlorpropamide or displaces it from binding siteresult in increase plasma concentration of chlorpropamide which may lead to enhanced hypoglycemic effect.ModerateClosely monitor for level of glucose whenever start or discontinuetherapy with chloramphenicol.Adjust the dose of chlorpropamide if necessary.ChymotrypsinCimetidine (HCl)CiprofloxacinCloxacillinChloramphenicol inhibit the effect of cloxacillin by inhibiting cellular protein synthesis and change bacteria into static one thus reducing the effectiveness of carbenicillin.ModerateCombination must be avoided. If necessary then cloxacillin administered several hours before chloramphenicol and closely observed.ClozapineClozapine due to additive effect increase the risk of hematologic toxicity result in severe agranulocytosis when given with chloramphenicol.MajorThis combination shoud not be use.Colistin (Sulphate & Sulphomethate Na)Cyanocobalaminchloramphenicol attenuate the effect of anemiaCyclophosphamideDicloxacillin (Na)Ethacrynic AcidDiuretics (e.g mannitol, hydrochlorothiazide, ethacrynic acid) increase renal excretion of chloramphenicol and its metabolites.EthinyloestradiolFloxacillin (Na)FosphenytoinGestodeneGlibornurideGliquidoneHydroxocobalaminIchthammolIron DextranIron SaltsIron SorbitolMecillinamMecobalaminNafcillinOxacillinParacetamolPhenobarbitonePhenobarbitonePhenobarbitone causes subtherapeutic concentration of chloramphenicol.Phenytoin (Na)Chloramphenicol increases he serum level of phenytin results in increased toxicity while phenytoin may increase or decrease the serum level of chlormphenicol.ModerateConcomitant use should be avoided. Closely monitor for serum concentration of phenytoin and observe for sign of toxicity.Piperacillin (Na)Pivmecillinam (HCl)PrimidoneProcaine PenicillinPromethazine (HCl)RifampicinRifampicinRifampicin causes subtherapeutic concentration of chloramphenicol.SulfapyridineConcurrent use of sulfapyridine with bone marrow depressants may increase the leukopenic or thrombocytopenic effects of these medications.If concurrent use is required, close observation for myelotoxic effects should be considered.Sultamicillin chloramphenicol may interfere with the bactericidal effect of penicillins; Aviod concurrent therapyTolbutamideHalf life and serum concentration of tolbutamide is increased when given with chloramphenicol.TolbutamideWarfarin (Na)Chloramphenicol may enhance the anticoagulant effect of Warfarin.ModerateConcurrent therapy with Dicumarol and Chloramphenicol should probably be avoided. Little is known regarding the risks of concurrent therapy with Warfarin and Chloramphenicol. If these two agents are used together, monitor for increased effects of Warfarin (eg, prothrombin time, and signs and symptoms of bleeding) at initiation of therapy and if dose of Chloramphenicol is increased. If Chloramphenicol is discontinued or dose decreased, monitor for decreased effects of Warfarin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interferes with the determination of total protein & blood urea nitrogen. Effects the determination of urine sugar, 17-ketosteroids & 17-OH corticosteroids.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps, Oral Susp, Dry Powder for Inj Store at room temperature. Protect from Sunlight. Cream, Syrup, Eye Ointment, Eye Drops, Ear Soln Store in a well closed container, at room temperature. Do not Freeze. Protect from Sunlight. Inj (reconstituted soln) Store at room temperature. Use within 24-48 hrs if kept at room temperature.

Evaluate blood count after every 2 days during therapy of chloramphenicol. Avoid concurrent therapy with other drugs that may cause bone marrow depression. It should be used with caution in case of liver or kidney disease. Discontinue therapy if secondry infection occurs.