ZIRENZ EFAVIR EFAVIR

Dose: 600 mg
Single Dose: 600 (600)
Frequency: 24 hourly
Route: PO
Instructions:

. It is of Synthetic origin. . The Molecular Weight of Efavirenz is 315.70.

Efavirenz is contraindicated in conditions like Breast feeding.

The severe or irreversible adverse effects of Efavirenz, which give rise to further complications include Insomnia, Amnesia.The symptomatic adverse reactions produced by Efavirenz are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Vomiting, Diarrhea, Anxiety, Abdominal pain, Rashes, Pruritus, Sleep disturbance, Crystalluria, Sinusitis, Abnormal dreams, dizziness, abnormal dreams, Suicidal ideations, Elevated liver enzyme, Fetal Hepatitis.

Efavirenz is primarily indicated in conditions like Epidural block, surgery, HIV infection.

Efavirenz is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDolutegravirEfavirenz decreases plasma dolutegravir dolutegravir dosage must be increasedKetoconazoleVORICONAZOLEEfavirenze may decrease the serum concentration of voriconazole likely by increasing its metabolism. Consider alternate therapy or adjust doses These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT)

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Chronic hepatitis B or C (greatest risk of hepatic side effects), hepatic impairment (avoid if severe); severe renal impairment; pregnancy; elderly; history of mental illness or seizures. RASH: rash usually in first 2 weeks, is the most common side effect; discontinue if severe rash or if rash accompanied by blistering, oral lesions, conjunctivitis, facial oedema, general malaise, or hypersensitivity reaction; if rash mild to moderate may continue without interruption but usually resolves within 1 month.