Cilostazole

Cilostazole is a vasodilator and an inhibitor of platelet agreggation. Cilostazole is used in the management of some peripheral vascular disorders.Cilostozol is a newer phosphodiesterase inhibitor that promotes vasodilation and inhibition of platelet aggregation. cilostozol is used primary to treat intermittant claudication.

Brands
PLATOR PLATOR LOSTAZ LOSTAZ PLETAAL PLETAAL LABISTA LABISTA WALK-AID WALK-AID
Adult Dose
Dose: 100 mg
Single Dose: 100 (100)
Frequency: 12 hourly
Route: PO
Instructions: Should be taken 30 min before or 2 hours after breakfast and dinner.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Quinolinone. . The Molecular Weight of Cilostazole is 369.50.
Contraindications
Cilostazole
Effects
The severe or irreversible adverse effects of Cilostazole, which give rise to further complications include Rhinitis, Rhinitis, Palpitation, Angina, Oedema, Abnormal stools.The signs and symptoms that are produced after the acute overdosage of Cilostazole include Hypotension, Tachycardia, Diarrhea, Cardiac arrhythmias.The symptomatic adverse reactions produced by Cilostazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Diarrhea, Palpitation, Irregular heart beat, Rashes, Shortening of breath, Sore throat, dizziness.
Indications
Cilostazole is primarily indicated in conditions like Intermittant claudication, Long-term treatment of reflux oesophagitis, Peripheral vascular disease, and can also be given in adjunctive therapy as an alternative drug of choice in Secondary prevention of ischaemic stroke and tias.
Interactions
Cilostazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmprenavirAmprenavir possibly increases plasma concentration of Cilostazol. ADVICE: Avoid concomitant use.Amrinone (Lactate)phosphoiestase inhitorsImmediateAspirinCimetidine (HCl)CisaprideClopidogrelDiltiazem (HCl)ErythromycinKetoconazoleLansoprazoleMidazolamNifedipineOmeprazoleRiociguatClinical experience with co-administration is limitedVerapamil (HCl)VORICONAZOLEVoriconzole may increase the serum concentration of cilostazol by decreasing its metabolism. Monitor for increased therapeutic/adverse effects of cilostazol and consider reducing the dose during concomitant therapy. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Abnormal LFTs Increased blood glucose level
Risks
Drug should not be given to Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Below 30°C.
Warnings
The patient should be carefully observed and given supportive treatment. Since cilostazol is highly protein-bound, it is unlikely that it can be efficiently removed by hemodialysis or peritoneal dialysis.Advise patients to report any episode of bleeding or bruising. Atrial ventricular ectopy atrial fibrillation or flufter, diabetes.
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