Mivacurium (Cl)

Mivacurium (Cl) is a benzylisoquinolinium, a competative neuromuscular blocker similar to atracurium. Mivacurium (Cl) is used to produce muscle relaxation in general anaesthesia for surgical procedures and also to assist mechanical ventilation. It has a short duration of action than most other competitive neuromuscular blockers. Mivacurium (Cl) is metabolised by plasma cholinestarase and muscle paralysis is prolonged in individuals deficient in this enzyme. Mivacurium (Cl) is not associated with parasympatholytic or ganglionic blockade although histamine release may occur, perticularly with rapid injection.

Brands

Adult Dose

Dose: 0.1 mg/kg
Single Dose: 0.1 (0.1)
Frequency: As recommended.
Route: IV
Instructions: Maintaenance dose should be given at 15 min interval.

Neonatal

Paedriatic

Dose: 100 ug/kg
Single Dose: 100 (100)
Frequency: As recommended.
Route: Every 6-9 month (maintnance dose)
Instructions:

Characteristics

. It is of Synthetic origin and belongs to Benzylesoqiunolinium. . The Molecular Weight of Mivacurium (Cl) is 1100.20.

Contraindications

Mivacurium (Cl) is contraindicated in conditions like Hypersensitivity,Cholinesterase deficiency.

Effects

Mivacurium (Cl) produces potentially life-threatening effects which include Hypotension, Bronchospasm, Bronchospasm, Erythema, Prolongation of neuromuscular blockade. which are responsible for the discontinuation of Mivacurium (Cl) therapy.The signs and symptoms that are produced after the acute overdosage of Mivacurium (Cl) include Hypotension, Paralysis of respiratory muscle.

Indications

Mivacurium (Cl) is primarily indicated in conditions like Adjunct to anesthesia, Muscle relaxation, Muscle relaxation (short duration) for surgery.

Interactions

Mivacurium (Cl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBambuterolDesfluraneDesfluraneEdrophonium (Cl)EnfluraneIsofluranePancuronium (Br)Procainamide (HCl)Rocuronium (Br)SevofluraneSuxamethonium (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

Risks

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

IV Inj, IV Inf Store at room temperature. Do not Freeze. Protect from Sunlight.

Warnings

Use with caution in patients with bronchial asthma. Exercise special caution, especially when histamine release would be hazardous, especially in patients with significant cardiovascular diseases. It should be used with cuation in pateints with plasma cholinesterase deficiency.

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