Leuprolide (Acetate)

Leuprolide (Acetate) is a gonadorelin analogue. Leuprolide (Acetate) is used for the supression of gonadal sex hormone secretions, in the treatment of advanced prostate cancera and breast cancer. Leuprolide (Acetate) is used as hormonal therapy in the treatment of endometriosis. Leuprolide is administered parenterally. It was approved by the FDA in April 1985 and came off patent in 1996. The depot formulation of leuprolide is indicated for treating uterine fibroid tumors, endometriosis, and advanced prostate cancer.

Brands
LORELIN LORELIN LECTRUM LECTRUM LUCONAL LUCRIN DEPOT LUCRIN DEPOT
Adult Dose
Dose: 3.75 mg
Single Dose: 3.8 (3.75)
Frequency: As recommended.
Route: IM
Instructions: Endometriosis_x000D_This dose should be administer monthly or 11.25 mg should be given every 3 months. (depot preparation).
Neonatal
Paedriatic
Characteristics
Leuprolide (Acetate) also known as Leuprorelin Acetate. . It is of Synthetic origin and belongs to Hormone. . The Molecular Weight of Leuprolide (Acetate) is 1269.50. Its pKa is 6, 10, 13.
Contraindications
Leuprolide (Acetate) is contraindicated in conditions like Vaginal bleeding,Hypersensitivity,Lactation.
Effects
The severe or irreversible adverse effects of Leuprolide (Acetate), which give rise to further complications include Leucopenia, Urinary retention, Angina, Bone pain, Myocardial infarction, Flare phenomenon, Urinary retention, Increased size of uterine myomata, Bowel obstruction, Bowel obstruction.The symptomatic adverse reactions produced by Leuprolide (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Palpitation, Light-headedness, Nervousness, Abdominal pain, Peripheral edema, Impotence, Weight gain, Dry skin, Hot flushes, Acne, Gynecomastia, Decrease in libido, Mood changes, nervousness, Nervousness, parasthesia, athralgia, Change in scalp, Body hair.
Indications
Leuprolide (Acetate) is primarily indicated in conditions like Breast cancer, Endometriosis, Intractable premenstrual syndrome, Prostatic cancer, Shrinkage of fibroids before surgery, and can also be given in adjunctive therapy as an alternative drug of choice in Uterine fibroids.
Interactions
No data regarding the interactions of Leuprolide (Acetate) was found.
Interfrence
Interfere with the diagnostic test of pituitary gonadotropic and the gonad function
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store at room temperature. Do not Freeze. Protect from Sunlight and Heat.
Warnings
Leuprolide injection (not the depot) formulation use with caution in the patients hypersensitive to benzyl alcohol. Long-term safety of leuprolide in children has not been established. At the initiation of the therapy tumor flare, bone pain and urinary tract obstruction may occur. Patient with life threatening diseases in which the rapid symptomatic relief is essential should be treated extremely cautiously with leuprolide. The drug should not be administered during pregnancy.
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