Nafarelin (Acetate)

Nafarelin (Acetate) is an analogue of gonadorelin with similar properties. Administration of gonadorelin analogues produces stimulation and causes reduction in the release of gonadotrophins (Follicle-stimulating hormone and luteinising hormone), which ultimately leads to inhibition of androgen and estrogen synthesis. Nafarelin (Acetate) is used in the treatment of endometriosis, precocious puberty, infertility anemia due to uterine fibroidsbreast cancer, prostate cancer and prior to intra-uterine surgery.

Brands
Adult Dose
Dose: 400 mcg
Single Dose: 400 (400)
Frequency: As recommended.
Route: IN
Instructions: 200 mcg (base) into one nostril in the morning and 200 mcg into the other nostril in the evening for 6 months.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Nafarelin (Acetate) is 1322.50. Its pKa is 10.98.
Contraindications
Nafarelin (Acetate) is contraindicated in conditions like Osteoporosis,Vaginal bleeding,Pregnancy,Lactation.
Effects
Nafarelin (Acetate) produces potentially life-threatening effects which include Chest pain, Decreased invertebral trabecular bone mass, Shortness of breath, Urticaria, Pruritis. which are responsible for the discontinuation of Nafarelin (Acetate) therapy.The symptomatic adverse reactions produced by Nafarelin (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Myalgia, Rashes, Hot flushes, Acne, Changes in libido, Vaginal dryness, Ovarian cyst, Irritation of nasal mucosa.
Indications
Nafarelin (Acetate) is primarily indicated in conditions like Benign prostatic hypertrophy, Endometriosis, Preparation of endometrial resection, Shrinkage of fibroids before surgery, and can also be given in adjunctive therapy as an alternative drug of choice in Infertility, Pituitary desensitisation.
Interactions
No data regarding the interactions of Nafarelin (Acetate) was found.
Interfrence
Pregnanediol Test Increased Alkaline Phosphatase LevelsGonadal function testingIncreased serum phosphate level
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Nasal Spray Store at room temperature, Below 30°C. Do not Freeze. Protect from Sunlight.
Warnings
Children treated for central precocious puberty should be closely monitored by the physician, during and after nafarelin treatment for central precocious puberty. Possibility of amenorrhea or irregular menstrual periods; checking with physician if regular menstruation does not occur within 60 to 90 days after discontinuation of medication.Using a water-based vaginal lubricant if painful sexual intercourse or vaginal dryness is a problem. Medication should be stopped if pregnany is suspected.
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