Nisoldipine

'Nisoldipine is a calcium-channel antagonist with actions and uses similar to those of nifedipine. It belongs to dihydropyridine class of calcium-channel antagonist that includes nifedipine, amlodipine, felodipine isradipine. In general, the dihydropyridine-type calcium-channel antagonists have more prominent effects on vasodilation and coronary flow than do diltiazem and verapamil. Nisoldipine is used in the treatment of Prinzmetal''s angina, hypertension, and other vascular disorders such as Raynaud''s phenomenon.'

Brands
Adult Dose
Dose: 8.5 to 34 mg
Single Dose: 21 (21.25)
Frequency: 24 hourly
Route: PO
Instructions: For Angina Pectoris Prophylaxis, Hypertension:_x000D_Maintenance dose:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Dihydophyidine calcium autogoust. . The Molecular Weight of Nisoldipine is 388.40.
Contraindications
Nisoldipine is contraindicated in conditions like Shock,Cardiac failure,Pulmonary hypertension,Hepatic dysfunction,Hypersensitivity,Pregnancy,Lactation,Aortic stenosis.
Effects
Nisoldipine produces potentially life-threatening effects which include Myocardial infarction, Worsening angina. which are responsible for the discontinuation of Nisoldipine therapy.The signs and symptoms that are produced after the acute overdosage of Nisoldipine include Heart failure., Hypotension, Bradyarrhythmias.The symptomatic adverse reactions produced by Nisoldipine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tiredness, Headache, Palpitation, Flushing, Hot swollen legs and feets.
Indications
Nisoldipine is primarily indicated in conditions like Angina, Hypertension, Mild to moderate hypertension, Prophylaxis of angina.
Interactions
Nisoldipine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDigoxinPropranolol (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of nisoldipine by decreasing its metabolism. Concomitant therapy should be avoided. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature. Protect from Sunlight.
Warnings
It should be used with caution in patients with kidney or liver disease. Consider decrease in dose of calcium channel blockers and monitor drug response in cirrhosis patients.
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