Dose: 6 to 24 mg/day
Single Dose: 15 (15)
Frequency: As recommended.
Route: PO
Instructions:

. It is of Synthetic origin and belongs to Sulfamoyl Benzoic Acid Derivative. . The Molecular Weight of Piretanide is 362.40. Its pKa is 3.9.

Piretanide is contraindicated in conditions like Gout,Hypovolaemia,Hypokalaemia,Anuria,Hepatic coma,Hypersensitivity,Pregnancy,Lactation,Dehydration.

The severe or irreversible adverse effects of Piretanide, which give rise to further complications include Thrombocytopenia, Ototoxicity, Orthostatic hypotension, Dehydration, Leucopenia, Hyponatremia, Urinary retention, Gout.Piretanide produces potentially life-threatening effects which include Cardiac arrhythmia, Renal failure, Hypotension, Increased renal excretion of Ca, K, Mg. which are responsible for the discontinuation of Piretanide therapy.The signs and symptoms that are produced after the acute overdosage of Piretanide include Dehydration, Delirium, Hypovolemia, Decreased sodium and water.The symptomatic adverse reactions produced by Piretanide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Urticaria, Erythema, Itching, Digestive disturbances.

Piretanide is primarily indicated in conditions like Ascites, Chronic liver disease, Hypertension, Nephrotic syndrome, Oedema in congestive heart failure, Pulmonary edema, Renal insufficiency, and can also be given in adjunctive therapy as an alternative drug of choice in Prophylaxis of renal transplant rejection.

Piretanide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineCarbenoxolone (Na)LithiumNoradrenaline (Acid Tartrate)PerindoprilInfrequent reports of PIRETANIDE increasing the HYPOTENSIVE effect of Perindopril Erbumine . ModerateProbenecid These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store Below 25°C. Protect from Sunlight.

It should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. It should be used with caution while engaging in activities requiring alertness. This drug changes fluid balance, cause dizziness, if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. It should be used with caution during pregnancy or lactation.