CONGNEX CONGNEX CONGNEX CONGNEX

Dose: 10 mg
Single Dose: 10 (10)
Frequency: 6 hourly
Route: PO
Instructions: For 6 weeks.

. It is of Synthetic origin. . The Molecular Weight of Tacrine (HCl) is 252.70. Its pKa is 9.9.

Tacrine (HCl) is contraindicated in conditions like Anesthesia,Cardiovascular disease,Hypersensitivity,GI diseases,Pulmonary disease.

The severe or irreversible adverse effects of Tacrine (HCl), which give rise to further complications include Transaminase elevation.The signs and symptoms that are produced after the acute overdosage of Tacrine (HCl) include Bradycardia, Hypotension, Nausea, Vomiting, Convulsions, Sweating, Muscular weakness, Increased salivation.The symptomatic adverse reactions produced by Tacrine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Nausea, Vomiting, Anorexia, Diarrhea, Constipation, Abdominal pain, Bradycardia, Skin RashX, Dyspepsia, Change in BP.

'Tacrine (HCl) is primarily indicated in conditions like Alzheimer''s disease, Dementia, Respiratory depression.'

Tacrine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBethanechol (Cl)Cimetidine (HCl)ClemastineFluvoxamine (Maleate)GlycopyrrolateHydrocortisoneOxymorphoneTacrine antagonizes the respiratory-depressant and sedative effects of morphine without altering its analgesic effects. The mechanism may be related both to the cholinergic effects of tacrine and to alterations in the metabolic fate of morphine. Other narcotic analgesics may participate in this interaction as well.MinorPantothenic AcidPantothenic Acid may increase the effects of Tacrine (HCl).ParegoricTacrine antagonizes the respiratory-depressant and sedative effects of morphine without altering its analgesic effects. The mechanism may be related both to the cholinergic effects of tacrine and to alterations in the metabolic fate of morphine. Other narcotic analgesics may participate in this interaction as well.MinorTheophylline These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Liver Function Test (LFT) Monitoring of liver enzymes

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Caps Store at room temperature. Protect from Moisture.

It should be used only if clearly needed during pregnancy. It should be used with caution in patients with asthma, seizure disorder, epilapsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, thyroid disorders, intestinal disorders, ulcers, urinary problems, impaired liver function or who have a history of such impairment or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increase absorption from the gastrointestinal tract. Serum-alanin aminotransferase concentrations should be monitored in patients receiving cintinuous treatment with tacrine. Monitoring should be carried out every other week for atleast the first first 16 weeks of therapy, followd by monthly for 2 months an dthen every 3 months thereafter. Weekly monitoring is recommended in patients with elevated aminotransferase levels that are greater than twice the upper limit of the normal range. If sign of liver involvment worsen, the dose should be reduced or withdrawn. Tacrine should be taken on an empty stomach to improve absorption. The initial dose is given for a minimum of 6 weeks. Dosage should not be increased during this period because the potential exists for a delay in onset of increased liver enzyme concentration. Serum-alanin aminotransferase concentrations should be monitored regularly and if there is no significant increase doses may be increased.