Tetrabenazine

A fibrous material containing Hemicellulose 40%, cellulose 20%, lignin 15%, and pectin 5%. It is an ideal bulking agent. It not only absorbs free water in the small intestine but also entraps a much large amount of water in the form of bacteria and cells inside the distal gut.


Brands
Adult Dose
Dose: 12.5 mg
Single Dose: 12 (12.5)
Frequency: 8 hourly
Route: PO
Instructions: This can be increased by 12.5 mg a day every 3 to 5 days until the maximal tolerated and effective dose is reached for the individual, and may have to be up/down titrated depending on individual tolerance. In most cases the maximal tolerated dose will be 25 mg t.i.d. In very rare cases, a 200 mg dose has been reached .
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Ketone. . The Molecular Weight of Tetrabenazine is 317.40.
Contraindications
Tetrabenazine is contraindicated in conditions like Depression,Parkinsonism,Hypotension.
Effects
Tetrabenazine produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Depression. which are responsible for the discontinuation of Tetrabenazine therapy.The symptomatic adverse reactions produced by Tetrabenazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Fatigue, Nausea, Anxiety, Insomnia, Nervousness, Sweating, Rashes, Confusion, Parkinsonism, Agitation, Dystonia, nervousness.
Indications
Tetrabenazine is primarily indicated in conditions like Chronic hyperkinetic movement disorders.
Interactions
Tetrabenazine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDroperidolLithiumVORICONAZOLEAdditive QTc prolongation may occur. Concomitant therapy should be avoided. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevation in ALT or AST
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, at room temperature, Below 30°C.
Warnings
It should be used with caution while engaging in activities requiring alertness. Dose may be increased gradually acccording to the response of patient. Dizziness or vertigo may affect the performance of skilled tasks (e.g driving)
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