ACCOLATE ZAFIR ZAIR ZAIR ZAKULATE 3H NOVILOKAST NOVILOKAST FREAIR BENALUCOST ZUKAST ZUKAST NEFES ZILESTA ZILESTA Z-SAF ZAFIRO ZAFIRO Z-KAST

Dose: 20 mg
Single Dose: 20 (20)
Frequency: 12 hourly
Route: PO
Instructions:

. It is of Synthetic origin. . The Molecular Weight of Zafirlukast is 575.50.

Zafirlukast is contraindicated in conditions like Hypersensitivity,Renal impairment,Hepatic impairment.

The severe or irreversible adverse effects of Zafirlukast, which give rise to further complications include Hyperbilirubinemia, Symptomatic hepatitis.Zafirlukast produces potentially life-threatening effects which include Neuropathy, Cardiac complication. which are responsible for the discontinuation of Zafirlukast therapy.The symptomatic adverse reactions produced by Zafirlukast are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fever, Myalgia, Pain, GI disturbance, Respiratory tract infections.

Zafirlukast is primarily indicated in conditions like Allergic rhinitis, Prophylaxis of asthma.

Zafirlukast is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinAspirin increases plasma concentration of leukotriene antagonists (e.g Zafirlukast).ErythromycinTheophyllineWarfarin (Na)Zafirlukast may decrease the metabolism, via CYP isoenzymes, of Warfarin.Moderate (Sequence important)Monitor for increased prothrombin time (PT)/effects of Warfarin if zafirlukast is initiated/dose increased, or decreased PT/effects if zafirlukast is discontinued/dose decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store in a well closed container, Between 20°C-25°C. Do not Freeze. Protect from Sunlight and Moisture.

Withdrawl may lead to recurrence of the symptoms of asthma. If withdrawl is necessary, it has been suggested that the dose should be reduce gradually over a period of one week.