Riluzole

Riluzole is a glutamate antagonist used for the treatment of amyotrophic lateral sclerosis, a form of motor neuron disease which produces muscular atrophy and weakness.


Brands
Adult Dose
Dose: 50 mg
Single Dose: 50 (50)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Riluzole is 234.20.
Contraindications
Riluzole is contraindicated in conditions like Neutropenia,Pregnancy,Lactation,Increase liver transaminase.
Effects
Riluzole produces potentially life-threatening effects which include Neutropenia. which are responsible for the discontinuation of Riluzole therapy.The symptomatic adverse reactions produced by Riluzole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Tachycardia, Pain, Asthenia, Abdominal distress, Hypertonia.
Indications
Riluzole is primarily indicated in conditions like Motor neuron disease.
Interactions
No data regarding the interactions of Riluzole was found.
Interfrence
Abnormal LFTs Increased Alkaline Phosphatase Levels+ve Coomb`s tests
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature. Protect from Sunlight.
Warnings
Liver fuction tests should be carried out before and throughout the tratment. White blood cell counts should be determined in fibrile illness and riluzole discontinued if neutripenia occurs. Extreme caution should be excercized in patients with renal impairment or those with a previous history of liver disorders. It should be used with caution while engaging in activities requiring alertness.
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