ZAVUD ZAVUD TRIOMUNE TRIOMUNE

Dose: 30 mg
Single Dose: 30 (30)
Frequency: 12 hourly
Route: PO
Instructions: Preferably at least 1 hr before food.

Stavudine also known as d4T. . It is of Synthetic origin. . The Molecular Weight of Stavudine is 224.20.

Stavudine is contraindicated in conditions like Pancreatitis,Peripheral neuropathy,Hypersensitivity,Renal dysfunction.

The severe or irreversible adverse effects of Stavudine, which give rise to further complications include Dysesthesia.Stavudine produces potentially life-threatening effects which include Pancreatitis, Peripheral neuropathy. which are responsible for the discontinuation of Stavudine therapy.The symptomatic adverse reactions produced by Stavudine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Drowsiness, Fatigue, Anorexia, Diarrhea, Fever, Myalgia, Anxiety, Dyspnea, Rashes, Urticaria, Depression, Cough, Arthralgia, Nausea and vomiting, GI disturbance, Abnormal dreams.

Stavudine is primarily indicated in conditions like HIV infection.

Stavudine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDoxorubicin (HCl)IsoniazidMetronidazolePentamidineRibavirinRibavirin may antagonize the cell culture antiviral activity of stavudine against HIV. Vincristine (Sulphate)Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Increases Serum Bilirubin Increased transaminases levels

Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Cap, Oral Soln Store in a well closed container, at room temperature.

It should be used with caution in patients with renal impairemnt. It should be used carefully in patients with a history of peripheral neuropathy and treatment suspended if neuropathy develops. If symptoms resolves on withdrawal stavudine may be resumed at half the previous dose. Patients with ahistory of pancreatitis should also be observed carefully for the signs of pancreatitis during treatment.