Dicloxacillin (Na)

Dicloxacillin (Na) is a semisynthetic penicillinase-resistant penicillin. Dicloxacillin (Na) is an agent of choice for most staphylococcal infections.


Brands
Adult Dose
Dose: 500 mg
Single Dose: 500 (500)
Frequency: As recommended.
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Semi Synthetic origin and belongs to Penicillin. . The Molecular Weight of Dicloxacillin (Na) is 510.30. It is weakly acidic drug.
Contraindications
Dicloxacillin (Na) is contraindicated in conditions like Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Dicloxacillin (Na), which give rise to further complications include Pseudomembranous colitis, Gi bleeding, Hepatitis, Cholestatic jaundice, Stevens johnson syndrome, Epidermal necrolysis.The symptomatic adverse reactions produced by Dicloxacillin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Abdominal pain, Maculopapular rash, Urticaria, Phlebitis, Elevation of liver enzymes, Vasculitis, Bullous rash.
Indications
Dicloxacillin (Na) is primarily indicated in conditions like Bone and joints infections, Bronchitis, Cellulitis, Lower respiratory tract infections, Pharyngitis, Pneumonia, Skin infections, Staphlococcal infections, Staphylococcal infections, Upper respiratory tract infections, Urinary tract infection.
Interactions
No data regarding the interactions of Dicloxacillin (Na) was found.
Interfrence
Creatinine determination by Alkaline Picrate Method Abnormal LFTs
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Below 25°C. Oral Susp (reconstituted) Store in refrigerator. Do not Freeze. Use within 2 weeks if kept at room temperature.
Warnings
Dicloxacillin is a penicillin and should not be used in patients with penicillin hypersensitivity. Dicloxacillin should be used cautiously in patients with cephalosporin hypersensitivity or imipenem hypersensitivity because these patients are more susceptible to hypersensitivity reactions. Patients with allergies or allergic conditions including asthma, eczema, hives, or hay fever may have a greater risk for hypersensitivity reactions to penicillins. Overgrowth of nonsusceptible organisms can occur during dicloxacillin therapy. Penicillins should be used with caution in patients with a history of GI disease, especially colitis. Also, patients who develop diarrhea while taking or soon after taking penicillins should be considered for differential diagnosis of antibiotic-associated pseudomembranous colitis. Penicillins are excreted in breast milk. Penicillins may cause diarrhea, candidiasis, and skin rash in breast-feeding infants. The potential risk to the infant should be considered versus the potential benefit in the mother.
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