Divalproex (Na)

Divalproex (Na) is a synonym of semisodium valproate (an united states approved name USAN), an antiepileptic used perticularly in the treatment of primary generalised seizures, and also for partial seizures. its action are complex and its mode of action is not fully understood. Divalproex (Na) is also used to treat the acute manic attacksand for the prophylaxis of migraine.

Brands
VALROX NEUROL-EP NEUROL-EP DIVALP DIVALP DIVALP VALPORX VALPORX VALPORX
Adult Dose
Dose: 750 mg
Single Dose: 750 (750)
Frequency: 24 hourly
Route: PO
Instructions: For mania
Neonatal
Paedriatic
Characteristics
Valproate semisodium is the derivative of Divalproex (Na). It is of Synthetic origin. . The Molecular Weight of Divalproex (Na) is 310.40.
Contraindications
Divalproex (Na) is contraindicated in conditions like Liver diseases.
Effects
The severe or irreversible adverse effects of Divalproex (Na), which give rise to further complications include Thrombocytopenia, Leucopenia, Bone marrow depression.The symptomatic adverse reactions produced by Divalproex (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Weight gain, Edema, Increased appetite.
Indications
Divalproex (Na) is primarily indicated in conditions like Generalized seizures, Partial seizures.
Interactions
Divalproex (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMephenytoinDivalproex (Na) may interact with Mephenytoin. It can either increase or decrease the effect of Mephenytoin. phenobarbital. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Altered thyroid function test
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps, Tab Store in a well closed container, at room temperature, Between 15°C-25°C. Inj Store at room temperature.
Warnings
It should be used with caution in patients with liver disease, bleeding disorder, history of a brain disorder or any allergy. It should be used with caution while driving motor vehicles or performing tasks that require alertness. Before having surgery, including dental surgery, inform the doctor about the use of drug. This may interfere with urine ketone testing and give false positive results, if very high sugar readings (e.g. over 300) are occurring, ketones may be present in urine, contact the doctor or pharmacist. It should be used with extreme caution in children under 2 years old as serious liver problems exist. The drug is not recommended for use during pregnancy or lactation. Treatment should be stopped if pancreatitis is tecognized.
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