Oxycodone

Oxycodone is a phenantherne derivative with opiod analgesic activity similar to morphine but adverse effects are milder than those of morphine. Oxycodone is used to control moderate to severe pain, including postoperative, postextractional, and postpartum pain. it, and other opiates such as morphine and codeine act as agonists at opiate receptors within the central nervous system (CNS). Opiate receptors include µ (mu), ? (kappa), d (delta), and s (sigma) and function as inhibitory modulators of synaptic transmission in both the CNS and the myenteric plexus.Clinically, stimulation of µ and ? receptors produces analgesia, euphoria, respiratory depression, miosis, decreased gastrointestinal motility, and physical dependence. It was approved by the FDA in 1976 and is a schedule C-II controlled substance.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
Oxycodone Terephthalate is the derivative of Oxycodone. It is of Synthetic origin. . The Molecular Weight of Oxycodone is 351.80.
Contraindications
Oxycodone is contraindicated in conditions like Peptic ulcer,Liver damage,Bleeding,Platelet dysfunction,Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Oxycodone, which give rise to further complications include Hallucinations, Anaphylactic reactions.The signs and symptoms that are produced after the acute overdosage of Oxycodone include Pulmonary edema, Convulsions, Coma, Respiratory depression, Respiratory depression, Renal failure.The symptomatic adverse reactions produced by Oxycodone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Restlessness, Constipation, Dry mouth, Confusion, Nausea and vomiting.
Indications
Oxycodone is primarily indicated in conditions like Moderate to moderately severe pain, Moderate to severe pain.
Interactions
Oxycodone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCisaprideCyclizineDomperidoneOxycodone antagonize the action of domperidone.Metoclopramide (HCl)MexiletineRitonavir These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Cap, Oral Soln Store in a well closed container, at room temperature. Protect from Sunlight.
Warnings
Oxycodone should be given with caution or in reduced doses to patients with hypothyroidism, adrenocortical insufficiency, asthma or decreased respiratory reserve, renal or hepatic impairment, prostatic hyperplasia, hypotension, shock, inflammatory or obstructive bowel disorders, or myasthenia gravis. Dosage should be reduced in elderly or debilitated patients. Oxycodone should be given with great care to infants, especially neonates. Their use during labour may cause respiratory depression in the neonate. Discontinuation of therapy with Oxycodone should be carried out gradually in patients who may have developed physical dependence, to avoid precipitating withdrawal symptoms. Drowsiness may affect the ability to perform skilled tasks; those so affected should not drive or operate machinery.
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