Zileuton

Zileuton is a lipoxygenase inhibitor that has been used in asthma but is not as popular as the receptor inhibitor. It works by blocking the formation of substances that cause inflammation, fluid retention, mucous secretion, and constriction in lungs

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Zileuton is 236.30.
Contraindications
Zileuton
Effects
The severe or irreversible adverse effects of Zileuton, which give rise to further complications include Leucopenia, Raised liver enzyme activity.The symptomatic adverse reactions produced by Zileuton are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Head stroke, GI disturbance.
Indications
Zileuton is primarily indicated in conditions like Asthma.
Interactions
Zileuton is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementTheophyllineWarfarin (Na)Zileuton may increase the serum concentration of Warfarin. ModerateMonitor for increased effects of Warfarin if Zileuton is initiated/dose increased and decreased effects if Zileuton is discontinued/dose decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature, Between 20°C-25°C.
Warnings
It should not be used in patients with hepatic impairment or active liver disease. It is not suitable for the treatemnt of acute asthma attacks.
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