Sirolimus

Sirolimus is a potent non-calcineurin inhibiting immunosuppressant. Sirolimus is given after kidney transplant to keep body from rejecting the new kidney. It can cause hyperlipidemias. It has been shown to possess antifungal and antineoplastic properties. Sirolimus is often given in conjunction with cyclosporin.

Brands
CERTICAN CERTICAN AFINITOR AFINITOR
Adult Dose
Neonatal
Paedriatic
Characteristics
. The Molecular Weight of Sirolimus is 914.20.
Contraindications
Sirolimus is contraindicated in conditions like Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Sirolimus, which give rise to further complications include Blood disorders.The symptomatic adverse reactions produced by Sirolimus are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Constipation, Abdominal pain, Nausea and vomiting, Hypersensitivity reactions, GI disturbance.
Indications
Sirolimus is primarily indicated in conditions like Autoimmune disease, Rejection of organ transplants, and can also be given in adjunctive therapy as an alternative drug of choice in Prophylaxis of organ rejection in kidney allograft recipients.
Interactions
Sirolimus is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCyclosporin AVORICONAZOLEVoriconazole may increase the serum concentration of sirolimus. Consider alternate therapy or reduce the dose These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Abnormal LFTs Increased Alkaline Phosphatase Levels
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tabs Store in a well closed container, Between 20°C-25°C. Protect from Moisture and Heat.
Warnings
'It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. While you are taking sirolimus, it is important to maintain good dental hygiene and see a dentist regularly for teeth cleaning. Sirolimus may lower your body''s resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take or have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid other persons who have taken the oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.'
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